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Table 1 Common differentially expressed gene of GSE5281 and GSE28146 datasets

From: Bioinformatic identification and experiment validation reveal 6 hub genes, promising diagnostic and therapeutic targets for Alzheimer’s disease

Name

Description

log2FoldChange

pval

up/down

YME1L1

YME1 like 1 ATPase

2.97

1.63E-04

up

KMT2A

lysine methyltransferase 2A

2.69

4.30E-03

up

C10orf90

chromosome 10 open reading frame 90

2.62

7.98E-04

up

EGFR

epidermal growth factor receptor

2.49

4.91E-02

up

FARP2

FERM, ARH/RhoGEF and pleckstrin domain protein 2

2.44

3.46E-03

up

CMYA5

cardiomyopathy associated 5

2.38

2.07E-03

up

NSUN3

NOP2/Sun RNA methyltransferase family member 3

2.31

1.45E-02

up

MAGI1

membrane associated guanylate kinase, WW and PDZ domain containing 1

2.28

3.57E-03

up

LOC101927027

uncharacterized LOC101927027

2.25

4.95E-03

up

NPAS3

neuronal PAS domain protein 3

2.23

1.36E-02

up

SLC25A37

solute carrier family 25 member 37

2.22

4.05E-03

up

NFYA

nuclear transcription factor Y subunit alpha

2.21

8.77E-03

up

SESN2

sestrin 2

2.19

2.80E-03

up

PIK3C2A

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

2.17

3.42E-02

up

PARD3B

par-3 family cell polarity regulator beta

2.16

5.22E-03

up

PAX8

paired box 8

2.15

3.87E-03

up

OR5J2

olfactory receptor family 5 subfamily J member 2

2.15

3.63E-03

up

IQSEC3

IQ motif and Sec7 domain 3

2.14

1.07E-03

up

EP400

E1A binding protein p400

2.13

3.60E-02

up

DOCK9

dedicator of cytokinesis 9

2.12

2.88E-02

up

MAP3K6

mitogen-activated protein kinase kinase kinase 6

2.08

1.21E-02

up

PHF19

PHD finger protein 19

2.06

8.62E-03

up

BUB1

BUB1 mitotic checkpoint serine/threonine kinase

2.05

1.77E-02

up

ELK4

ELK4, ETS transcription factor

2.04

5.34E-03

up

PRB1

proline rich protein BstNI subfamily 1

2.04

8.28E-04

up

EIF1AY

eukaryotic translation initiation factor 1A, Y-linked

−2.71

1.28E-02

down

MYH11

myosin heavy chain 11

−2.58

4.80E-04

down

MIR4683///FZD8

microRNA 4683///frizzled class receptor 8

−2.54

7.25E-03

down

COL11A1

collagen type XI alpha 1 chain

−2.46

2.52E-02

down

LOC100996385

uncharacterized LOC100996385

−2.45

7.87E-04

down

DUSP16

dual specificity phosphatase 16

−2.37

2.53E-03

down

FBXL17

F-box and leucine rich repeat protein 17

−2.37

1.40E-02

down

KIAA1841

KIAA1841

−2.33

7.73E-03

down

SLF2

SMC5-SMC6 complex localization factor 2

−2.28

4.31E-04

down

TMLHE

trimethyllysine hydroxylase, epsilon

−2.28

7.54E-03

down

VPS53

VPS53, GARP complex subunit

−2.25

8.13E-03

down

CDH7

cadherin 7

−2.14

2.08E-02

down

MYLIP

myosin regulatory light chain interacting protein

−2.13

9.11E-03

down

CAMSAP1

calmodulin regulated spectrin associated protein 1

−2.11

3.82E-03

down

SCFD1

sec1 family domain containing 1

−2.07

1.43E-02

down

CEP350

centrosomal protein 350

−2.06

1.12E-02

down

NMNAT2

nicotinamide nucleotide adenylyltransferase 2

−2.06

1.22E-02

down

DRP2

dystrophin related protein 2

−2.04

2.51E-02

down

TMF1

TATA element modulatory factor 1

−2.03

2.20E-02

down

CACNG4

calcium voltage-gated channel auxiliary subunit gamma 4

−2.03

6.73E-04

down

ARHGEF28

Rho guanine nucleotide exchange factor 28

−2.02

3.06E-02

down

FAM86B3P

family with sequence similarity 86, member A pseudogene

−2.02

2.45E-02

down

IKZF3

IKAROS family zinc finger 3

−2.00

2.24E-02

down

UBASH3B

ubiquitin associated and SH3 domain containing B

−1.97

1.34E-02

down

NELFCD

negative elongation factor complex member C/D

−1.97

1.85E-02

down