Fig. 3

GO/KEGG Enrichment Analysis of Differentially Expressed Iron Metabolism-related Genes. A-C Annular diagrams of GO enrichment analysis results at the BP (A), CC (B), and MF (C) levels. The outmost side of the left circle is the GO term ID. The middle ring represents upregulated and downregulated genes. Each dot represents one gene that is enriched in this GO term. The color of the innermost circle represents the z-score. A gene that is closer to red has a greater upregulation degree. The length of the color bar represents the adjusted P-value. A longer color bar means a smaller adjusted p-value. D Bubble chart of KEGG enrichment results. The x-axis represents gene ratio; color represents adjusted p-value; the red labels on the y-axis represent the enrichment results of upregulated iron metabolism-related genes, and the blue labels represent the enrichment results of downregulated iron metabolism-related genes. The x-axis represents the gene ratio, i.e., the number of genes enriched in the pathway/the total number of differentially expressed genes. The y-axis represents pathways. The size of the dots represents the number of genes enriched in a pathway. The color represents the adjusted p-value. Dark blue represents a smaller adjusted p-value. E KEGG enrichment pathways of upregulated iron metabolism-related genes. The dot size represents a number of genes in the pathway. The pink color bar represents fold change value of genes. The number of dots represents gene entrez ID.