Analysis | OR | Lower 95%CI | Upper 95%CI | p | SNPs, n | Horizontal pleiotropy | Heterogeneity | ||
---|---|---|---|---|---|---|---|---|---|
Egger intercept | P | Q | P | ||||||
Years of schooling | |||||||||
MR Egger | 0.866 | 0.605 | 1.238 | 0.487 | 5 | 0.014 | 0.453 | 39.029 | 6.871E-08 |
Weighted median | 1.025 | 0.993 | 1.058 | 0.125 | |||||
Inverse variance weighted | 1.010 | 0.943 | 1.081 | 0.786 | |||||
Simple mode | 1.021 | 0.918 | 1.137 | 0.720 | |||||
Weighted mode | 1.029 | 0.985 | 1.074 | 0.268 | |||||
College or university degree | |||||||||
MR Egger | 0.967 | 0.781 | 1.198 | 0.781 | 5 | 0.004 | 0.740 | 26.411 | 2.615E-05 |
Weighted median | 1.020 | 0.999 | 1.041 | 0.060 | |||||
Inverse variance weighted | 1.006 | 0.969 | 1.045 | 0.760 | |||||
Simple mode | 1.026 | 0.990 | 1.065 | 0.235 | |||||
Weighted mode | 1.026 | 1.003 | 1.049 | 0.093 | |||||
Intelligence | |||||||||
MR Egger | 0.853 | 0.608 | 1.197 | 0.426 | 5 | 0.016 | 0.382 | 15.143 | 0.004 |
Weighted median | 1.055 | 1.010 | 1.102 | 0.017 | |||||
Inverse variance weighted | 1.015 | 0.951 | 1.083 | 0.658 | |||||
Simple mode | 1.048 | 0.991 | 1.108 | 0.178 | |||||
Weighted mode | 1.050 | 1.006 | 1.096 | 0.089 | |||||
Income | |||||||||
MR Egger | 0.753 | 0.618 | 0.919 | 0.068 | 5 | 0.025 | 0.074 | 13.684 | 0.008 |
Weighted median | 0.970 | 0.930 | 1.012 | 0.160 | |||||
Inverse variance weighted | 0.984 | 0.924 | 1.048 | 0.613 | |||||
Simple mode | 0.935 | 0.871 | 1.003 | 0.134 | |||||
Weighted mode | 0.966 | 0.917 | 1.017 | 0.256 | |||||
Social deprivation | |||||||||
MR Egger | 1.186 | 0.977 | 1.441 | 0.184 | 5 | -0.016 | 0.173 | 13.523 | 0.009 |
Weighted median | 0.990 | 0.958 | 1.023 | 0.552 | |||||
Inverse variance weighted | 0.998 | 0.951 | 1.046 | 0.919 | |||||
Simple mode | 0.987 | 0.945 | 1.031 | 0.584 | |||||
Weighted mode | 0.986 | 0.949 | 1.024 | 0.505 | |||||
Attention-deficit hyperactivity disorder | |||||||||
MR Egger | 1.856 | 0.648 | 5.315 | 0.368 | 4 | -0.055 | 0.372 | 1.537 | 0.674 |
Weighted median | 1.011 | 0.831 | 1.229 | 0.916 | |||||
Inverse variance weighted | 1.015 | 0.854 | 1.205 | 0.868 | |||||
Simple mode | 0.932 | 0.701 | 1.239 | 0.662 | |||||
Weighted mode | 1.052 | 0.822 | 1.347 | 0.713 | |||||
Bipolar disorder | |||||||||
MR Egger | 0.988 | 0.422 | 2.311 | 0.979 | 5 | 0.005 | 0.906 | 0.672 | 0.955 |
Weighted median | 1.058 | 0.863 | 1.296 | 0.590 | |||||
Inverse variance weighted | 1.043 | 0.881 | 1.235 | 0.625 | |||||
Simple mode | 0.956 | 0.734 | 1.246 | 0.757 | |||||
Weighted mode | 1.094 | 0.874 | 1.369 | 0.479 | |||||
Major depressive disorder | |||||||||
Inverse variance weighted | 1.033 | 0.744 | 1.436 | 0.845 | 2 | NA | NA | 18.057 | 2.143E-05 |
Schizophrenia | |||||||||
MR Egger | 1.219 | 0.742 | 2.002 | 0.491 | 5 | -1.839E-02 | 0.487 | 2.138 | 0.710 |
Weighted median | 0.990 | 0.885 | 1.107 | 0.860 | |||||
Inverse variance weighted | 1.001 | 0.914 | 1.097 | 0.975 | |||||
Simple mode | 1.003 | 0.869 | 1.158 | 0.965 | |||||
Weighted mode | 0.983 | 0.860 | 1.124 | 0.817 | |||||
Anxiety disorders | |||||||||
MR Egger | 0.999 | 0.986 | 1.013 | 0.932 | 5 | 1.197E-01 | 0.884 | 7.325 | 0.120 |
Weighted median | 1.000 | 0.997 | 1.002 | 0.674 | |||||
Inverse variance weighted | 1.000 | 0.998 | 1.003 | 0.714 | |||||
Simple mode | 0.999 | 0.995 | 1.003 | 0.735 | |||||
Weighted mode | 0.999 | 0.996 | 1.001 | 0.450 |