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Table 4 Frequency of NAT2 alleles compared to published data of other African populations

From: Towards pharmacogenomics-guided tuberculosis (TB) therapy: N-acetyltransferase-2 genotypes among TB-infected Kenyans of mixed ethnicity

NAT2 allele

Mutation site

Allele frequencies

Kenya (this study)

Kenya [21]a

Africa [19]b

Africa [26]c

Senegal [7]d

Zulu [33]e

1000 Genome Project [34]f

NAT2*4

Wildtype

37%

22%

17%g

27%

9%g

4%g

NA

NAT2*13

282C > T

29%

NA

14%

NA

5%g

NA

47%

NAT2*12

803A > G

6%

NA

15%

NA

13%

28%g

39%g

NAT2*11

481C > T

4%

NA

NA

NA

NA

1%

24%g

NAT2*5

341 T > C

18%

38%g

27%

33%

36%g

7%

29%

NAT2*6

590G > A

6%

25%g

26%g

30%g

NA

NA

24%g

  1. aNAT2 allele frequencies for Kenya’s Bantu and Nilotic populations [21]
  2. bNAT2 allele frequencies for diverse African populations from Kenya, Nigeria, Tanzania and Zimbabwe [19]
  3. cNAT2 allele frequencies for diverse African populations from Tanzania, South African Venda, and Zimbabwe [26]
  4. dNAT2 allele frequencies for the African ancestry of Madenka in Senegal [7]
  5. eNAT2 allele frequencies for Zulu-speaking South Africans [33]
  6. fNAT2 allele frequencies for the African ancestry of the Caribbean in Barbados, south-west US, Esan in Nigeria, Gambian in Western Division, the Gambia, Luhya in Webuye, Kenya, Mende in Sierra Leone, Yoruba in Ibadan, Nigeria. The allele frequencies from the different regions did not differ significantly (χ2, p < 0.05) from each other, so the overall frequency was used for this comparative analysis [34]
  7. gSignificant difference (χ2, p < 0.05) in comparison with the proportion of NAT2 alleles among Kenyan volunteers found in this study
  8. NA Not Applicable (Not Determined or Specified)
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BMC Medical Genomics

ISSN: 1755-8794

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