Table 1 Odd ratios (ORs) and 95% CI of NIHL-associated SNPs in the screening stage

1

CDH23

rs2394795

Recessive

AA + AB/BB

2.190 (1.040, 4.789)

0.043

2.437 (1.133, 5.446)

0.025

Dominant

AA/BB + AB

0.705 (0.340, 1.467)

0.352

0.610 (0.272, 1.323)

0.216

Super-dominant

AA + BB/AB

0.746 (0.402, 1.376)

0.349

0.752 (0.399, 1.411)

0.375

Homozygote

BB/AA

2.423 (0.960, 6.317)

0.064^#

4.068 (1.383, 13.605)

0.015

The allele

B/A

1.472 (0.957, 2.273)

0.080^#

1.976 (1.148, 3.459)

0.015

2

FAS

rs1468063

Recessive

BB/AA + AB

2.456 (1.176, 5.341)

0.019

2.308 (1.090, 5.089)

0.032

Dominant

AA/BB + AB

0.896 (0.466, 1.717)

0.740

0.877 (0.445, 1.722)

0.704

Super-dominant

AA + BB/AB

2.101 (1.131, 3.951)

0.020

2.090 (1.100, 4.023)

0.026

Homozygote

AA/BB

1.857 (0.799, 4.442)

0.155

1.792 (0.742, 4.444)

0.199

The allele

A/B

1.307 (0.848, 2.018)

0.226

1.382 (0.845, 2.272)

0.199

3

FAS

rs2862833

Recessive

BB/AA + AB

0.945 (0.487, 1.830)

0.866

0.934 (0.468, 1.862)

0.845

Dominant

BB + AB/AA

2.510 (1.223, 5.341)

0.014

2.437 (1.170, 5.274)

0.020

Super-dominant

AA + BB/AB

1.899 (1.025, 3.558)

0.043

1.884 (0.992, 3.617)

0.054^#

Homozygote

BB/AA

2.080 (0.903, 4.92)

0.089^#

2.101 (0868, 5.247)

0.104

The allele

B/A

1.438 (0.934, 2.221)

0.100

1.584 (0.965, 2.621)

0.071^#

4

FOXO3

rs2802292

Recessive

BB/AA + AB

1.561 (0.536, 4.859)

0.420

1.427 (0.484, 4.497)

0.524

Dominant

AA/BB + AB

0.643 (0.345, 1.188)

0.160

0.683 (0.360, 1.286)

0.239

Super-dominant

AA + BB/AB

1.902 (1.000, 3.673)

0.052^#

1.735 (0.894, 3.408)

0.105

Homozygote

AA/BB

1.235 (0.412, 3.948)

0.709

1.132 (0.367, 3.706)

0.831

The allele

A/B

0.830 (0.508, 1.353)

0.456

0.818 (0.474, 1.408)

0.468

5

FOXO3

rs10457180

Recessive

BB/AA + AB

1.758 (0.621, 5.395)

0.298

1.617 (0.564, 5.023)

0.381

Dominant

AA/BB + AB

0.710 (0.382, 1.311)

0.274

0.762 (0.403, 1.439)

0.403

Super-dominant

AA + BB/AB

1.810 (0.950, 3.498)

0.074^#

1.636 (0.839, 3.223)

0.150

Homozygote

AA/BB

1.433 (0.491, 4.515)

0.518

1.337 (0.448, 4.297)

0.609

The allele

A/B

0.912 (0.560, 1.483)

0.710

0.918 (0.535, 1.575)

0.757

6

GAPDH

rs6489721

Recessive

BB/AA + AB

1.000 (0.441, 2.268)

1.000

1.009 (0.439, 2.324)

0.984

Dominant

AA/BB + AB

0.727 (0.381, 1.377)

0.329

0.732 (0.366, 1.453)

0.373

Super-dominant

AA + BB/AB

1.336 (0.727, 2.469)

0.352

1.314 (0.696, 2.490)

0.400

Homozygote

AA/BB

0.813 (0.327, 2.013)

0.652

0.946 (0.356, 2.551)

0.911

The allele

A/B

0.861 (0.555, 1.334)

0.503

0.801 (0.477, 1.341)

0.399

7

GJB2

rs3751385

Recessive

BB/AA + AB

2.436 (1.232, 4.951)

0.012

2.553 (1.260, 5.348)

0.011

Dominant

AA/BB + AB

1.181 (0.615, 2.280)

0.618

1.333 (0.681, 2.629)

0.402

Super-dominant

AA + BB/AB

1.851 (0.987, 3.516)

0.057^#

1.715 (0.898, 3.309)

0.104

Homozygote

AA/BB

2.108 (0.957, 4.748)

0.067^#

2.349 (1.030, 5.532)

0.046

The allele

A/B

1.546 (1.004, 2.389)

0.049

1.798 (1.111, 2.933)

0.018

8

HDAC2

rs10499080

Recessive

BB/AA + AB

0.850 (0.381, 1.878)

0.687

0.775 (0.339, 1.753)

0.540

Dominant

AA/BB + AB

0.544 (0.269, 1.080)

0.085^#

0.550 (0.261, 1.135)

0.109

Super-dominant

AA + BB/AB

1.476 (0.801, 2.739)

0.213

1.371 (0.719, 2.626)

0.338

Homozygote

AA/BB

0.563 (0.219, 1.420)

0.225

0.589 (0.218, 1.571)

0.290

The allele

A/B

0.746 (0.483, 1.151)

0.186

0.623 (0.364, 1.056)

0.081^#

9

HOTAIR

rs874945

Recessive

BB/AA + AB

-

-

-

-

Dominant

AA/BB + AB

1.114 (0.585, 2.127)

0.743

1.108 (0.550, 2.144)

0.817

Super-dominant

AA + BB/AB

0.672 (0.343, 1.301)

0.240

0.731 (0.360, 1.467)

0.381

Homozygote

BB/AA

-

-

-

-

The allele

A/B

0.886 (0.506, 1.546)

0.671

0.896 (0.475, 1.684)

0.733

10

hOGG1

rs1052133

Recessive

BB/AA + AB

0.546 (0.281, 1.048)

0.071^#

0.580 (0.293, 1.135)

0.114

Dominant

AA/BB + AB

0.721 (0.320, 1.593)

0.421

0.674 (0.288, 1.539)

0.352

Super-dominant

AA + BB/AB

0.713 (0.386, 1.311)

0.278

0.780 (0.415, 1.460)

0.438

Homozygote

AA/BB

0.510 (0.204, 1.248)

0.143

0.494 (0.188, 1.261)

0.144

The allele

A/B

1.449 (0.937, 2.248)

0.096^#

1.610 (0.960, 2.725)

0.073^#

11

PTPRN2

rs10081191

Recessive

BB/AA + AB

1.897 (0.626, 6.418)

0.270

2.083 (0.653, 7.428)

0.228

Dominant

AA/BB + AB

0.679 (0.367, 1.249)

0.215

0.659 (0.346, 1.242)

0.199

Super-dominant

AA + BB/AB

1.810 (0.976, 3.389)

0.061^#

1.961 (1.020, 3.831)

0.046

Homozygote

AA/BB

1.473 (0.466, 5.155)

0.520

1.480 (0.435, 5.577)

0.540

The allele

A/B

0.892 (0.557, 1.426)

0.632

0.839 (0.486, 1.442)

0.525

12

SIK3

rs6589574

Recessive

BB/AA + AB

0.468 (0.140, 1.383)

0.184

0.482 (0.141, 1.480)

0.214

Dominant

BB + AB/AA

2.186 (0.244, 0.847)

0.014

2.355 (1.247, 4.523)

0.009

Super-dominant

AA + BB/AB

1.725 (0.930, 3.229)

0.085^#

1.892 (0.999, 3.632)

0.052^#

Homozygote

AA/BB

3.000 (0.972, 10.398)

0.064^#

2.938 (0.899, 10.656)

0.082^#

The allele

A/B

1.830 (1.141, 2.959)

0.013

2.242 (1.292, 3.948)

0.005

13

STAT3

rs1053023

Recessive

BB/AA + AB

2.637 (0.928, 8.627)

0.082^#

5.207 (1.103, 32.315)

0.049

Dominant

AA/BB + AB

1.052 (0.562, 1.974)

0.873

1.101 (0.566, 2.144)

0.776

Super-dominant

AA + BB/AB

0.679 (0.367, 1.249)

0.215

0.704 (0.369, 1.334)

0.283

Homozygote

AA/BB

0.430 (0.125, 1.307)

0.152

0.596 (0.159, 2.053)

0.420

The allele

A/B

0.855 (0.545, 1.338)

0.493

0.849 (0.485, 1.482)

0.566

14

STAT3

rs1053005

Recessive

BB/AA + AB

3.338 (1.106, 12.367)

0.045

6.038 (1.223, 40.273)

0.039

Dominant

AA/BB + AB

1.000 (0.534, 1.871)

1.000

1.039 (0.536, 2.015)

0.908

Super-dominant

AA + BB/AB

0.679 (0.367, 1.249)

0.215

0.704 (0.369, 1.334)

0.283

Homozygote

BB/AA

3.000 (0.933, 11.637)

0.081^#

2.278 (0.633, 9.517)

0.224

The allele

A/B

0.810 (0.516, 1.270)

0.359

0.784 (0.446, 1.371)

0.394

15

Table 2

rs521845

Recessive

BB/AA + AB

0.753 (0.314, 1.768)

0.516

0.786 (0.320, 1.902)

0.592

Dominant

AA/BB + AB

1.512 (0.805, 2.865)

0.200

1.550 (0.811, 2.987)

0.186

Super-dominant

AA + BB/AB

0.586 (0.315, 1.080)

0.088^#

0.584 (0.308, 1.097)

0.096^#

Homozygote

BB/AA

1.019 (0.394, 2.594)

0.969

1.190 (0.437, 3.246)

0.732

The allele

A/B

1.135 (0.730, 1.768)

0.574

1.218 (0.725, 2.054)

0.457