Table 2 ORs and 95% CI of NIHL-associated SNPs in the replication stage

1

CDH23

rs2394795

Recessive

BB/AA + AB

2.261 (1.361, 3.872)

0.002

2.358 (1.336, 4.313)

0.004

Dominant

AA/BB + AB

1.562 (0.954, 2.550)

0.075^#

1.527 (0.869, 2.674)

0.139

Super-dominant

AA + BB/AB

0.777 (0.516, 1.167)

0.226

0.739 (0.467, 1.163)

0.194

Homozygote

BB/AA

2.704 (1.437, 5.181)

0.002

3.024 (1.438, 6.549)

0.004

The allele

B/A

1.522 (1.144, 2.027)

0.004

1.505 (1.099, 2.065)

0.011

2

FAS

rs1468063

Recessive

AA + AB/BB

1.861 (1.124, 3.085)

0.016

1.950 (1.113, 3.423)

0.019

Dominant

AA/BB + AB

0.813 (0.540, 1.228)

0.324

0.756 (0.477, 1.197)

0.233

Super-dominant

AA + BB/AB

1.804 (1.221, 2.816)

0.004

2.077 (1.302, 3.356)

0.002

Homozygote

AA/ BB

1.453 (0.837, 2.527)

0.184

1.427 (0.772, 2.639)

0.255

The allele

A/B

1.106 (0.827, 1.476)

0.496

1.084 (0.785, 1.495)

0.623

3

FAS

rs2862833

Recessive

AA + AB/BB

1.200 (0.788, 1.821)

0.394

1.349 (0.844, 2.156)

0.211

Dominant

BB + AB/AA

1.639 (1.013, 2.650)

0.043

1.722 (1.008, 2.942)

0.046

Super-dominant

AB/AA + BB

1.693 (1.123, 2.571)

0.013

2.006 (1.256, 3.248)

0.004

Homozygote

BB/AA

1.306 (0.763, 2.238)

0.330

1.205 (0.661, 2.193)

0.540

The allele

B/A

1.093 (0.820, 1.455)

0.543

1.054 (0.766, 1.448)

0.746

4

GJB2

rs3751385

Recessive

AA + AB/BB

2.659 (1.686, 4.218)

< 0.001

3.061 (1.823, 5.175)

< 0.001

Dominant

AA/BB + AB

1.712 (1.097, 2.709)

0.020

2.119 (1.289, 3.551)

0.034

Super-dominant

AB/AA + BB

1.381 (0.919, 2.084)

0.122

1.270 (0.807, 2.007)

0.303

Homozygote

AA/ BB

2.981 (1.736, 5.182)

< 0.001

3.731 (2.004, 7.150)

< 0.001

The allele

A/B

1.836 (1.379, 2.450)

< 0.001

2.106 (1.531, 2.909)

< 0.001

5

PTPRN2

rs10081191

Recessive

AA + AB/BB

1.109 (0.560, 2.146)

0.760

1.610 (0.760, 3.352)

0.205

Dominant

AA/BB + AB

1.370 (0.916, 2.052)

0.126

1.443 (0.921, 2.269)

0.110

Super-dominant

AB/AA + BB

1.437 (0.955, 2.173)

0.084^#

1.754 (1.105, 2.815)

0.018

Homozygote

AA/ BB

0.954 (0.459, 1.857)

0.933

1.181 (0.530, 2.588)

0.679

The allele

A/B

0.850 (0.623, 1.156)

0.304

0.894 (0.634, 1.255)

0.518

6

SIK3

rs6589574

Recessive

AA + AB/BB

0.804 (0.408, 1.526)

0.515

0.724 (0.345, 1.462)

0.378

Dominant

AA/BB + AB

1.550 (1.035, 2.325)

0.034

1.743 (1.113, 2.749)

0.016

Super-dominant

AB/AA + BB

1.437 (0.955, 2.173)

0.084^#

1.542 (0.980, 2.442)

0.063^#

Homozygote

AA/ BB

0.654 (0.323, 1.280)

0.224

0.599 (0.272, 1.267)

0.189

The allele

A/B

1.351 (0.994, 1.844)

0.056^#

1.472 (1.050, 2.077)

0.026

7

STAT3

rs1053023

Recessive

AA + AB/BB

0.632 (0.325, 1.172)

0.157

0.823 (0.408, 1.633)

0.600

Dominant

AA/BB + AB

1.168 (0.778, 1.761)

0.455

1.440 (0.914, 2.289)

0.119

Super-dominant

AA + BB/AB

1.418 (0.947, 2.127)

0.090^#

1.539 (0.985, 2.418)

0.059^#

Homozygote

AA/ BB

0.731 (0.363, 1.416)

0.364

1.030 (0.478, 2.172)

0.938

The allele

A/B

0.976 (0.724, 1.313)

0.874

1.159 (0.835, 1.610)

0.377

8

STAT3

rs1053005

Recessive

AA + AB/BB

0.632 (0.325, 1.172)

0.157

0.823 (0.408, 1.633)

0.600

Dominant

AA/BB + AB

1.168 (0.778, 1.761)

0.455

1.440 (0.914, 2.289)

0.119

Super-dominant

AA + BB/AB

1.418 (0.947, 2.127)

0.090^#

1.539 (0.985, 2.418)

0.059^#

Homozygote

AA/ BB

0.731 (0.363, 1.416)

0.364

1.030 (0.478, 2.172)

0.938

The allele

A/B

0.976 (0.724, 1.313)

0.874

1.159 (0.835, 1.610)

0.377