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Table 3 Associations between levels of GRS and risk for NIHL.

From: Interactions of genetic variations in FAS, GJB2 and PTPRN2 are associated with noise-induced hearing loss: a case-control study in China

GRS

total (n = 405)

NIHL (n = 153)

Control (n = 252)

p

OR (95% CI)

Median (P25, P75)

6.0 (4.0, 7.0)

7.0 (5.0, 8.0)

5.0 (4.0, 7.0)

< 0.001

 

GRS subgroup [n (%)]

     

≤ 5

188 (46.4)

48 (31.4)

140 (55.6)

-

1.000

6

35 (14.1)

22 (14.4)

35 (13.9)

0.058#

1.833 (0.973, 3.417)

7

63 (15.6)

31 (20.3)

32 (12.7)

0.001

2.826 (1.563, 5.131)

8

52 (12.8)

22 (14.4)

30 (11.9)

0.020

2.139 (1.1211, 4.054)

9

27 (6.7)

17 (11.1)

10 (4.0)

< 0.001

4.958 (2.160, 11.948)

≥ 10

18 (4.4)

13 (8.5)

5 (2.0)

< 0.001

7.583 (2.708, 24.661)

ptrend

   

0.043

 

< 6

188 (46.4)

48 (31.4)

140 (55.6)

 

1.000

≥ 6

217 (53.6)

105 (68.6)

112 (44.4)

< 0.001

2.734 (1.801, 4.195)

  1. Bold values indicate statistical significance
  2. # 0.05 ≤ p < 0.10