Interactions of genetic variations in FAS, GJB2 and PTPRN2 are associated with noise-induced hearing loss: a case-control study in China

Table 4 Risk estimate of gene-gene interaction in CART model

Terminal Node	Combinations of SNPs			n (Control/NIHL)	OR (95% CI)	p^*
Terminal Node	GJB2 rs3751385	FAS rs1468063	PTPRN2 rs10081191	n (Control/NIHL)	OR (95% CI)	p^*
1	AA/AB			206/96	1.000
2	BB	AA/AB	BB/AB	28/14	1.164 (0.527, 2.474)	0.699
3	BB	AA/AB	AA	14/27	4.250 (1.984, 9.539)	< 0.001
4	BB	BB		4/16	12.084 (3.923, 46.526)	< 0.001

Bold values indicate statistical significance
* Adjusted for age, sex, nationality, year of noise exposure, CNE, use of PPE, drinking and smoking status
AA, wild genotype; AB, heterozygous mutation genotype; BB, homozygous mutant genotype

ISSN: 1755-8794