Interactions of genetic variations in FAS, GJB2 and PTPRN2 are associated with noise-induced hearing loss: a case-control study in China

Table 5 Risk estimate of gene-environment interaction in CART model

Terminal Node	Combinations of environment				Combinations of SNPs			n (Control/NIHL)	OR (95% CI)	p
Terminal Node	PPE	CNE	Drinking	Age	GJB2 rs3751385	FAS rs1468063	PTPRN2 rs10081191	n (Control/NIHL)	OR (95% CI)	p
1				< 45	AA/AB			87/26	1.000	-
2		< 95	Yes	≥ 45	AA/AB	AA/AB		18/9	1.673 (0.651, 4.102)	0.269
3		< 95	No	≥ 45	AA/AB	AA/AB		15/12	2.677 (1.103, 6.447)	0.028
4	Yes	≥ 95		≥ 45	AA/AB	AA/AB		63/22	1.168 (0.604, 2.247)	0.641
5	No	≥ 95		≥ 45	AA/AB	AA/AB		3/9	10.038 (2.770, 47.792)	0.001
6				≥ 45	AA/AB	BB		20/18	3.012 (1.389, 6.567)	0.005
7					BB		BB/AB	31/23	2.483 (1.239, 4.998)	0.010
8					BB		AA	15/34	7.585 (3.654, 16.443)	< 0.001

Bold values indicate statistical significance
AA, wild genotype; AB, heterozygous mutation genotype; BB, homozygous mutant genotype

ISSN: 1755-8794