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Table 3 Multivariate logistic regression analysis between NPC1L1 and HMGCR gene polymorphisms and coronary artery calcification

From: Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease

Gene

SNP

Genetic Model

Total Population

(n = 872)

Male Population

(n = 635)

Female Population

(n = 237)

OR

95% CI

P

OR

95% CI

P

OR

95% CI

P

NPC1L1

rs11763759 T > C

Dominant

CC + CT/TT

1.069

0.633–1.804

0.803

0.967

0.510–1.832

0.918

1.331

0.527–3.365

0.545

  

Recessive

CC/CT + TT

–

–

–

–

–

–

–

–

–

  

Codominant

CC/CT/TT

0.997

0.608–1.635

0.991

0.893

0.493–1.617

0.708

1.331

0.527–3.365

0.545

 

rs4720470 C > T

Dominant

TT + CT/CC

1.224

0.874–1.713

0.239

1.505

1.008–2.249

0.046

0.742

0.396–1.391

0.352

  

Recessive

TT/CT + CC

0.945

0.556–1.607

0.836

1.281

0.705–2.328

0.416

0.397

0.115–1.373

0.144

  

Codominant

TT/CT/CC

1.100

0.862–1.404

0.442

1.311

0.985–1.746

0.063

0.710

0.439–1.150

0.164

 

rs2072183 G > C

Dominant

CC + GC/GG

1.126

0.799–1.589

0.498

1.079

0.719–1.619

0.712

1.266

0.657–2.440

0.481

  

Recessive

CC/GC + GG

1.255

0.792–1.990

0.334

1.227

0.714–2.108

0.460

1.249

0.515–3.031

0.623

  

Codominant

CC/GC/GG

1.128

0.885–1.436

0.330

1.097

0.825–1.458

0.524

1.196

0.753-1.900

0.449

 

rs2073547 A > G

Dominant

GG + GA/AA

1.107

0.785–1.562

0.563

1.029

0.687–1.542

0.889

1.343

0.691–2.609

0.385

  

Recessive

GG/GA + AA

1.216

0.768–1.924

0.405

1.171

0.683–2.007

0.567

1.260

0.519–3.056

0.609

  

Codominant

GG/GA/AA

1.108

0.871–1.411

0.404

1.058

0.797–1.404

0.696

1.235

0.775–1.968

0.374

HMGCR

rs12916 T > C

Dominant

CC + CT/TT

1.072

0.722–1.591

0.732

1.391

0.865–2.238

0.174

0.539

0.259–1.122

0.099

  

Recessive

CC/CT + TT

0.772

0.526–1.132

0.186

0.798

0.501–1.270

0.341

0.710

0.361–1.396

0.321

  

Codominant

CC/CT/TT

0.929

0.738–1.170

0.531

1.035

0.788–1.359

0.804

0.708

0.460–1.092

0.118

 

rs2303151 C > T

Dominant

TT + CT/CC

0.789

0.553–1.125

0.190

0.728

0.474–1.117

0.146

0.945

0.497–1.798

0.863

  

Recessive

TT/CT + CC

0.927

0.400-2.151

0.860

0.386

0.089–1.668

0.202

2.179

0.687–6.916

0.186

  

Codominant

TT/CT/CC

0.836

0.617–1.131

0.245

0.721

0.493–1.055

0.092

1.105

0.665–1.838

0.699

 

rs4629571 A > G

Dominant

GG + GA/AA

0.707

0.441–1.134

0.150

0.657

0.365–1.181

0.160

0.835

0.373–1.871

0.661

  

Recessive

GG/GA + AA

0.869

0.186–4.068

0.858

2.182

0.394–12.08

0.371

–

–

–

  

Codominant

GG/GA/AA

0.745

0.485–1.145

0.179

0.746

0.438–1.271

0.281

0.757

0.365–1.569

0.454

  1. OR: Odds Ratio; CI: Confidence Interval; SNP: Single nucleotide polymorphism; NPC1L1: Niemann-Pick C1-like 1; HMGCR: 3-hydroxy-3-methylglutaryl-coenzyme A Reductase
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BMC Medical Genomics

ISSN: 1755-8794

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