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Table 4 Sensitivity analysis in patients without prior use of statins

From: Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease

Gene

SNP

Genetic Model

Total Population

(n = 258)

Male Population

(n = 175)

Female Population

(n = 83)

OR

95% CI

P

OR

95% CI

P

OR

95% CI

P

NPC1L1

rs11763759 T > C

Dominant

CC + CT/TT

1.215

0.387–3.810

0.739

1.474

0.448–4.850

0.523

–

–

–

  

Recessive

CC/CT + TT

–

–

–

–

–

–

–

–

–

  

Codominant

CC/CT/TT

1.151

0.384–3.448

0.802

1.360

0.440–4.202

0.593

–

–

–

 

rs4720470 C > T

Dominant

TT + CT/CC

2.373

0.972–5.796

0.058

3.029

1.102–8.327

0.032

0.950

0.149–6.068

0.957

  

Recessive

TT/CT + CC

2.261

0.766–6.676

0.140

3.029

0.864–10.62

0.083

1.483

0.142–15.51

0.742

  

Codominant

TT/CT/CC

1.865

1.040–3.345

0.037

2.274

1.162–4.450

0.016

1.091

0.295–4.037

0.896

 

rs2072183 G > C

Dominant

CC + GC/GG

0.898

0.384–2.101

0.804

0.880

0.338–2.295

0.794

0.873

0.136–5.614

0.887

  

Recessive

CC/GC + GG

2.115

0.832–5.586

0.114

1.760

0.583–5.308

0.316

3.561

0.507–25.01

0.202

  

Codominant

CC/GC/GG

1.221

0.685–2.177

0.499

1.127

0.587–2.167

0.719

1.488

0.420–5.274

0.538

 

rs2073547 A > G

Dominant

GG + GA/AA

0.860

0.366–2.023

0.730

0.824

0.313–2.168

0.695

0.833

0.130–5.349

0.848

  

Recessive

GG/GA + AA

2.004

0.775–5.180

0.152

1.619

0.539–4.862

0.391

3.561

0.507–25.01

0.202

  

Codominant

GG/GA/AA

1.173

0.660–2.087

0.587

1.071

0.558–2.054

0.838

1.464

0.409–5.235

0.558

HMGCR

rs12916 T > C

Dominant

CC + CT/TT

7.639

0.999–58.43

0.050

6.555

0.844–50.90

0.072

–

–

–

  

Recessive

CC/CT + TT

1.550

0.643–3.737

0.329

1.222

0.434–3.439

0.704

2.854

0.437–18.62

0.273

  

Codominant

CC/CT/TT

1.857

0.987–3.496

0.055

1.695

0.830–3.314

0.152

2.840

0.542–14.89

0.217

 

rs2303151 C > T

Dominant

TT + CT/CC

1.603

0.697–3.686

0.267

1.130

0.434–2.941

0.802

6.610

0.700-62.42

0.099

  

Recessive

TT/CT + CC

1.639

0.341–7.873

0.537

0.868

0.101–7.472

0.898

3.901

0.333–45.72

0.278

  

Codominant

TT/CT/CC

1.458

0.763–2.788

0.254

1.063

0.490–2.307

0.878

3.392

0.896–12.83

0.072

 

rs4629571 A > G

Dominant

GG + GA/AA

0.998

0.322–3.092

0.998

1.027

0.277–3.804

0.968

1.033

0.106–10.01

0.978

  

Recessive

GG/GA + AA

–

–

–

–

–

–

–

–

–

  

Codominant

GG/GA/AA

0.910

0.322–2.570

0.859

0.986

0.279–3.483

0.983

0.834

0.128–5.441

0.849

  1. OR: odds ratio; CI: confidence interval; SNP: single nucleotide polymorphism; NPC1L1: Niemann-Pick C1-like 1; HMGCR: 3-hydroxy-3-methylglutaryl-coenzyme a reductase
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BMC Medical Genomics

ISSN: 1755-8794

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