Volume 6 Supplement 1

Proceedings of the 2011 International Conference on Bioinformatics and Computational Biology (BIOCOMP'11)

Research

Edited by Ke K Zhang, Hamid R Arabnia and Mehdi Pirooznia

Publication of this supplement has been supported by the International Society of Intelligent Biological Medicine.

The 2011 International Conference on Bioinformatics and Computational Biology (BIOCOMP'11). Go to conference site.

Las Vegas, NV, USA

18-21 July 2011

  1. Introduction

    The current trend of genomics research for human diseases

    This is an introduction to the supplement to BMC Medical Genomics that includes16 papers selected from the 2011 World Congress in Computer Science, Computer Engineering, Applied Computing as well as other sources...

    Ke K Zhang, Hamid R Arabnia, Yunliang Wang and Youping Deng

    BMC Medical Genomics 2013 6(Suppl 1):S1

    Published on: 23 January 2013

  2. Research

    Short and long term gene expression variation and networking in human proximal tubule cells when exposed to cadmium

    Cadmium (Cd2+) is a known nephrotoxin causing tubular necrosis during acute exposure and potentially contributing to renal failure in chronic long-term exposure. To investigate changes in global gene expression e...

    Scott H Garrett, Kaitlin Clarke, Donald A Sens, Youping Deng, Seema Somji and Ke K Zhang

    BMC Medical Genomics 2013 6(Suppl 1):S2

    Published on: 23 January 2013

  3. Research

    Identification of regulatory regions of bidirectional genes in cervical cancer

    Bidirectional promoters are shared promoter sequences between divergent gene pair (genes proximal to each other on opposite strands), and can regulate the genes in both directions. In the human genome, > 10% o...

    Guohua Wang, Ke Qi, Yuming Zhao, Yu Li, Liran Juan, Mingxiang Teng, Lang Li, Yunlong Liu and Yadong Wang

    BMC Medical Genomics 2013 6(Suppl 1):S5

    Published on: 23 January 2013

  4. Research

    Breast cancer subtyping from plasma proteins

    Early detection of breast cancer in blood is both appealing clinically and challenging technically due to the disease's illusive nature and heterogeneity. Today, even though major breast cancer subtypes have b...

    Fan Zhang and Jake Y Chen

    BMC Medical Genomics 2013 6(Suppl 1):S6

    Published on: 23 January 2013

  5. Research

    Potential roles of microRNAs in regulating long intergenic noncoding RNAs

    Over 10,000 long intergenic non-coding RNAs (lincRNAs) have been identified in the human genome. Some have been well characterized and known to participate in various stages of gene regulation. In the post-tra...

    Liran Juan, Guohua Wang, Milan Radovich, Bryan P Schneider, Susan E Clare, Yadong Wang and Yunlong Liu

    BMC Medical Genomics 2013 6(Suppl 1):S7

    Published on: 23 January 2013

  6. Research

    Assessment of gene order computing methods for Alzheimer's disease

    Computational genomics of Alzheimer disease (AD), the most common form of senile dementia, is a nascent field in AD research. The field includes AD gene clustering by computing gene order which generates highe...

    Benqiong Hu, Gang Jiang, Chaoyang Pang, Shipeng Wang, Qingzhong Liu, Zhongxue Chen, Charles R Vanderburg, Jack T Rogers, Youping Deng and Xudong Huang

    BMC Medical Genomics 2013 6(Suppl 1):S8

    Published on: 23 January 2013

  7. Research

    Detecting differentially methylated loci for Illumina Array methylation data based on human ovarian cancer data

    It is well known that DNA methylation, as an epigenetic factor, has an important effect on gene expression and disease development. Detecting differentially methylated loci under different conditions, such as ...

    Zhongxue Chen, Hanwen Huang, Jianzhong Liu, Hon Keung Tony Ng, Saralees Nadarajah, Xudong Huang and Youping Deng

    BMC Medical Genomics 2013 6(Suppl 1):S9

    Published on: 23 January 2013

  8. Research

    Integrated lipidomics and transcriptomic analysis of peripheral blood reveals significantly enriched pathways in type 2 diabetes mellitus

    Insulin resistance is a key element in the pathogenesis of type 2 diabetes mellitus. Plasma free fatty acids were assumed to mediate the insulin resistance, while the relationship between lipid and glucose dis...

    Chen Zhao, Jinghe Mao, Junmei Ai, Ming Shenwu, Tieliu Shi, Daqing Zhang, Xiaonan Wang, Yunliang Wang and Youping Deng

    BMC Medical Genomics 2013 6(Suppl 1):S12

    Published on: 23 January 2013

  9. Research

    A novel method for the normalization of microRNA RT-PCR data

    MicroRNAs (miRNAs) are short non-coding RNA molecules that regulate mRNA transcript levels and translation. Deregulation of microRNAs is indicated in a number of diseases and microRNAs are seen as a promising ...

    Rehman Qureshi and Ahmet Sacan

    BMC Medical Genomics 2013 6(Suppl 1):S14

    Published on: 23 January 2013

  10. Research

    Development of a novel DNA sequencing method not only for hepatitis B virus genotyping but also for drug resistant mutation detection

    In HBV-infected patients, different genotypes of the hepatitis B virus influence liver disease progression and response to antiviral therapy. Moreover, long-term antiviral therapy will eventually select for dr...

    Fanjun Wang, Lili Lu, Changshun Yu, Zhanwu Lv, Xuelian Luo, Chao Wan, Zhaohui Hu, Qinyi Zhu, Youping Deng and Chuyu Zhang

    BMC Medical Genomics 2013 6(Suppl 1):S15

    Published on: 23 January 2013

  11. Research

    HDAM: a resource of human disease associated mutations from next generation sequencing studies

    Next generation sequencing (NGS) technologies have greatly facilitated the rapid and economical detection of pathogenic mutations in human disorders. However, mutation descriptions are hard to be compared and ...

    Meiwen Jia, Yanli Liu, Zhongchao Shen, Chen Zhao, Meixia Zhang, Zhenghui Yi, Chengping Wen, Youping Deng and Tieliu Shi

    BMC Medical Genomics 2013 6(Suppl 1):S16

    Published on: 23 January 2013

  12. Research

    Exploring the pathogenetic association between schizophrenia and type 2 diabetes mellitus diseases based on pathway analysis

    Schizophrenia (SCZ) and type 2 diabetes mellitus (T2D) are both complex diseases. Accumulated studies indicate that schizophrenia patients are prone to present the type 2 diabetes symptoms, but the potential m...

    Yanli Liu, Zezhi Li, Meixia Zhang, Youping Deng, Zhenghui Yi and Tieliu Shi

    BMC Medical Genomics 2013 6(Suppl 1):S17

    Published on: 23 January 2013