Table 4 The fitted linear mixed effect models for each biomarker expression within Gleason grade 3+3 tumors, where zone of origin (TZ vs. PZ) was fitted as a fixed effect and patient as a random effect.

Bax

Intercept

2.73

0.18

-

TZ (vs. PZ)

-2.27

0.32

< 0.0001

Bcl-XL

Intercept

3.58

0.15

-

TZ (vs. PZ)

-0.25

0.15

0.12

Bin1

Intercept

2.13

0.25

-

TZ (vs. PZ)

-1.47

0.44

0.005

FAS

Intercept

0.27

0.22

-

TZ (vs. PZ)

-0.20

0.39

0.61

MDM2

Intercept

2.81

0.60

-

TZ (vs. PZ)

-2.81

1.04

0.02

P21

Intercept

2.67

0.28

-

TZ (vs. PZ)

-2.13

0.49

0.0008

P65

Intercept

1.67

0.37

-

TZ (vs. PZ)

-1.67

0.63

0.02