The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis

Table 3 Comparative transcriptomic analysis of normal human epithelial melanocytes to thin primary cutaneous and metastatic melanoma samples

Fold Higher Expression in Melanoma				Fold Lower Expression in Melanoma
Gene Symbol	NHEM c/t MIS/Thin	Gene Symbol	NHEM c/t Metastatic Melanoma	Gene Symbol	NHEM c/t MIS/Thin	Gene Symbol	NHEM c/t Metastatic Melanoma
KRT14	6787	GJA1	759	MME	106	MAP4	20
GJA1	5929	SEPP1	338	CITED1	77	OCA2	10
EHF	5487	KRT14	306	GDF15	64	TRIM7	7
SCEL	3931	MAGEA2	301	PAEP	47	CITED1	6
CLCA2	3689	TRAG3	242	RPEL1	45	TRPM4	6
S100A7	3609	EHF	193	HES6	43	MME	5
KRTDAP	3416	S100A9	160	ESDN	37	TRAP150	5
DSC1	2782	S100A7	129	QPRT	35	FER1L3	4
GJB6	2576	SCEL	126	OCA2	19	QPRT	4
CXCL14	2484	SLC22A3	125	RENBP	17	KLF8	4
LOR	2308	EPHA3	124	NR4A3	16	RPEL1	4
KRT6A	1989	KRTDAP	121	Siat7c	16	PACE4	4
PKP1	1835	S100A8	120	C6orf168	15	HPCAL1	4
SERPINB3	1778	ZIC1	119	BCL2A1	14	ACTR1A	4
S100A9	1768	CXCL14	118	NTT73	14	MET	3
KRT15	1545	IL18	108	PSCD3	14	RAB32	3
GATA3	1347	PRAME	102	HPCAL1	13	TYR	3
PPL	1339	MAGEA6	94.7	MET	12	IRF6	3
IMUP	1250	PLCB4	88	ALS2CR3	12	GDF15	3
ICEBERG	1123	CLCA2	87	PTPLA	12	HINT3	3
KRT6B	1114	GJB6	85	TBC1D7	11	SLC30A1	3
CSTA	693	MAGEA3	84	OA1	11	TRPV2	3
CST6	687	MMP19	59	TYR	11	RSN	3

NOTE: Abbreviations: NHEM: Normal Human Epithelial Melanocytes, c/t: Compared to, MIS, melanoma-in-situ, Thin, thin melanomas < 1.0 mm in Breslow's thickness

ISSN: 1755-8794