Heat map diagrams of differentially expressed genes on a high-fat diet. SLR of differentially expressed genes related to lipid metabolism (A), cell cycle (B) and inflammation/immune response (C) are clustered in a heat map diagram for the proximal, middle and distal part of the small intestine. Green and red indicate down- and up-regulation of gene expression, respectively. In general, three expression patterns can be distinguished; consistently up-regulated, consistently down-regulated or alternate up- and down-regulation during diet intervention. Amongst other genes that display similar expression patterns on a high-fat diet, the boxes include differentially expressed genes that share association with particular biological processes (numbered). Differentially expressed genes with a -0.3 > SLR > 0.3 in at least one week of diet intervention were included and the color scheme ranges from SLR -1.5 to 1.5.