Figure 2

Amplification models and clustered data from chromosome 1. A) Component distributions of the amplification model and B) Clustered DNA copy number amplification data are shown for chromosome 1. Amplification models are presented as amplification probabilities in each chromosome band. White to black scaling represents amplification probabilities from zero to one. Six component distributions of the amplification model (panel A) have been used to cluster data into six clusters (panel B). In panel B, each line represents a single cancer case in the data set and amplified chromosome bands are marked black. Models and clusters are separated using gray horizontal lines. Amplification patterns are marked in the figure by red boxes and cancer types that are associated with the amplification model-based cancer clusters are denoted in the figure. Chromosome band annotations were collected from the International System for Human Cytogenetic Nomenclature (2005) [26] and are marked below corresponding chromosome bands. Black and white chromosome bands according to G-banding are marked. In addition, chromosome bands with specific chromosomal properties, namely, centromeres (Cen), telomeres (Tel), fragile sites (Fra), and variable regions (Var), are marked.