Skip to main content

Table 4 Multivariable analysis to assess combined predictive ability of the best SNPs, risk factors, and interactions

From: Investigating the complex genetic architecture of ankle-brachial index, a measure of peripheral arterial disease, in non-Hispanic whites

Model

Adj R2

CV R2

Single Replicated and CVD SNPs

0.0065

0.0009

Single SNPs + Top 4 SNP*SNP Interactions

0.0515

0.0066

CVD Covariates

0.1252

0.1040

CVD Covariates + Single SNPs

0.1397

0.1178

CVD Covariates + Single SNPs + 3 SNP*Covariate Interactions

0.1504

0.1118

CVD Covariates + Single SNPs + Top 4 SNP*SNP Interactions

0.1652

0.0877

CVD Covariates + Single SNPs + 3 SNP*Covariate Interactions + Top 4 SNP*SNP Interactions

0.1785

0.0963

  1. CVD, cross-validated; SNPs, Single Nucleotide Polymorphisms