Figure 2

Over-expressed transcripts in a conditional mouse model for metastatic prostate cancer coincide with those expressed in normal cerebrum/cerebellum adult tissues. (a) Hierarchical clustering of gene expression profiles from normal and prostate cancer tissues in p53 ^PE-/-; Rb ^PE-/- mice showing clusters of up and down-regulated genes. Heatmap colours represent relative mRNA expression as indicated in the colour key. (b) A heat map generated by hierarchical clustering of normal prostate, cerebrum and cerebellum adult tissue gene expression (Oncogenomics data) for genes identified as differentially expressed in the p53 ^PE-/-; Rb ^PE-/- prostate cancer mouse model. Differentially expressed genes in prostate cancer tissue from the p53 ^PE-/-; Rb ^PE-/- mouse coincide with those of normal adult tissue from cerebrum and cerebellum and not from the normal prostate.