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Table 3 Combinations of neuroendocrine biomarkers are enriched in specific malignant tissue types.

From: Pro-neural transcription factors as cancer markers

Hes6

tumour. hits

Fgr

Bgr

p. value

Reference

Colon

93

252

1534

2.74E-014

[26, 38]

Uterus

39

94

1692

3.24E-008

-

Rectosigmoid

12

27

1759

0.00043528

-

Rectum

12

32

1754

0.00303994

-

Hes6/DDC

tumour. hits

Fgr

Bgr

p. value

Reference

Colon

197

252

1534

0

-

Rectosigmoid

21

27

1759

1.42E-009

-

Rectum

23

32

1754

5.03E-009

-

Liver

24

38

1748

1.65E-007

-

Kidney

75

214

1572

0.00040486

-

Stomach

5

8

1778

0.00476289

-

Hes6/CHGA

tumour. hits

Fgr

Bgr

p. value

Reference

Colon

89

252

1534

0

-

Uterus

42

94

1692

6.80E-013

-

Endometrium

30

71

1715

6.50E-009

-

Rectosigmoid

13

27

1759

1.02E-005

-

Rectum

13

32

1754

0.00011383

-

Stomach

4

8

1778

0.00324489

-

NTS

tumour. hits

Fgr

Bgr

p. value

Reference

Lung

36

108

1678

1.29E-010

[39]

Ovary

32

170

1616

0.00143643

[40]

Small intestine

3

6

1780

0.00226141

[41]

Ascl1

tumour. hits

Fgr

Bgr

p. value

Reference

Breast

40

317

1469

8.27E-008

-

Lung

20

108

1678

3.76E-007

[42, 43]

Ascl1/Hes6/NTS/DDC

tumour. hits

Fgr

Bgr

p. value

Reference

Lung

15

108

1678

3.79E-006

-

Rectosigmoid

4

27

1759

0.00421239

-

  1. A hypergeometric distribution was used to generate the p-values for each present tumour type. Tumour types mapping to less than 3 samples per group have been filtered out. References included do mention studies that relate the biomarker/s with human carcinoma tissue and most of them include very small sets of samples.
  2. Neuroendocrine biomarkers enrich for specific malignant tissue types in a multi-tumour dataset. Samples from the ExpO expression dataset were clustered based on the expression of neuroendocrine genesets (Hes6, Hes6-Chga, Hes6-Ddc, Ascl1, Ascl1-Hes6-Nts-Ddc). Clusters were defined by a median expression level with a threshold level three-fold greater than the average intensity across all samples. These sample groups were tested for enrichment of malignant tissue type when compared to the complete dataset as background. The p-values were calculated using a hyper-geometric distribution and represent the probability of obtaining the reported level of enrichment had the samples been selected at random.