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Table 2 Numerical internal scores.

From: Whole genome identification of Mycobacterium tuberculosisvaccine candidates by comprehensive data mining and bioinformatic analyses

Criterion

Internal score

Maximal score

Macrophage

(0) no evidence

3

 

(1) significant evidence from one source

 
 

(2) significant evidence from two sources

 
 

(3) significant evidence from > two sources + high value

 

MprAB

(0) no evidence

2

 

(1) <3.0 fold expression

 
 

(2) >3.0 fold expression

 

Hypoxia

(0) no evidence

2

 

(1) 1 evidence

 
 

(2) >1 evidence, high values

 

Reactivation

(0) no evidence

2

 

(1) evidence from one source

 
 

(2) evidence from two sources

 

Dormancy

(0) no evidence

2

 

(1) low values

 
 

(2) high values

 

Lung

(0) no evidence

2

 

(1) evidence from one source

 
 

(2) multiple evidences (or Rachman/Jain source)

 

acr-coregulated

(0) no evidence

2

 

(2) up regulated

 

Secreted

(0) no evidence

2

 

(1) secreted

 
 

(2) secreted+virulence-related function

 

B-cell immunogen

(0) no evidence

2

 

(1) evidence from one source

 
 

(2) multiple evidences

 

Iron regulated

(0) no evidence

2

 

(1) low values

 
 

(2) high values

 

Cell wall

(0) not related

2

 

(1) general association (without tm)

 
 

(2) virulence-related function

 

Vaccine

(0) no evidence

3

 

(1) DNA/protein immunization, immune respone but no protection

 
 

(2) part of a multivalent construct, protection

 
 

(3) DNA/protein vaccine protection

 

Repeats

(0) no repeats

2

 

(1) repeats only

 
 

(2) repeats + virulence-related function

 

T-cell

 

   Experimental

(0) no evidence

2

 

(1) evidence from one source

 
 

(2) multiple different evidences

 

   Predictions

(0) 0< #supertypes <6

2

 

(1) 6 < #supertypes <10

 
 

(2) 10<#supertypes <12

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