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Table 3 Top-ranking 45 antigens (sorted by quantitative and qualitative scores).

From: Whole genome identification of Mycobacterium tuberculosisvaccine candidates by comprehensive data mining and bioinformatic analyses

Group

Rv #

Gene (a)

Length (aa)

Annotation (a)

Qual Total

Quant Total

I

Rv1738

 

94

hypothetical protein

9

14

 

Rv2450c

rpfE

172

probable resuscitation-promoting factor rpfE [transglycosylase]

9

14

 

Rv2623

TB31.7

297

hypothetical protein TB31.7 [universal stress protein]

9

14

 

Rv1009

rpfB

362

possible resuscitation-promoting factor rpfB [transglycosylase, C5 adhesion domain]

9

13

 

Rv0867c

rpfA

407

possible conserved trans-membrane protein [transglycosylase, rpfA]

9

12

 

Rv2031c

acr (α-crystallin)

144

heat-shock protein HspX (alpha-crystallin homolog) 14 kDa antigen Hsp16.3

8

14

 

Rv1886c

fbpB (Ag85B)

325

secreted antigen 85-B FBPB (85-B) (mycolyl-transferase 85B)

8

14

 

Rv0288

esxH (TB10.4)

96

Low Mw protein antigen 7 esxH (10 kDa antigen) CFP-7, TB10.4)

8

13

 

Rv2032

acg

331

conserved hypothetical protein Acg [nitroreductase]

8

13

 

Rv2626c

 

143

hypothetical protein [CBS pair – binding/regulation, euk]

8

13

 

Rv3873

PPE68

368

PPE family protein [PPE68, RD1 T/B immunogen]

8

13

 

Rv2005c

 

295

hypothetical protein [USP-like]

8

12

 

Rv3127

 

344

hypothetical protein [possible nitroreductase]

8

12

II

Rv1733c

 

210

probable conserved trans-membrane protein

8

11

 

Rv1996

 

317

hypothetical protein [USP]

8

10

 

Rv2389c

rpfD

154

probable resuscitation-promoting factor rpfD [transglycosylase]

8

10

 

Rv0685

Tuf

396

elongation factor Tu [iron-regulated]

8

9

 

Rv2628

 

120

hypothetical protein

8

9

 

Rv1980c

mpb64

228

immunogenic protein MPT64

7

13

 

Rv3804c

fbpA (Ag85A)

338

secreted antigen 85-A FBPA (85-A) (mycolyl-transferase 85A)

7

13

 

Rv0079

 

273

hypothetical protein

7

11

 

Rv3130c

[tgs1]

463

hypothetical protein [diacylglycerol acyltransferase]

7

11

 

Rv3131

[bfnB]

332

hypothetical protein [possible nitroreductase NfnB]

7

11

 

Rv0824c

desA1

389

probable acyl [-acyl-carrier-desaturase desA1]

7

10

 

Rv1908c

katG

740

catalase-peroxidase-peroxinitritase-T katG

7

10

 

Rv1174c

[sak5]

110

Low Mw T-cell antigen TB8.4 [secretion antigen SA5K]

7

9

 

Rv1349

[irtB]

579

probable drugs transport ATP-binding protein ABC transporter [ATM1 ABC siderophore-iron transporter]

7

9

 

Rv1813c

 

143

hypothetical protein

7

9

 

Rv2006

otsB1

1327

probable trehalose-6-phosphate phosphatase OTSB1

7

9

 

Rv2029c

pfkB

339

possible phosphofructokinase (pfkB)

7

9

 

Rv2627c

 

413

hypothetical protein

7

9

 

Rv2780

ald

371

secreted L-alanine dehydrogenase ald (40 kDa antigen, TB43)

7

9

III

Rv1884c

rpfC

176

probable resuscitation-promoting factor rpfC [transglycosylase]

7

8

 

Rv2620c

 

141

probable conserved transmembrane protein

7

8

 

Rv2744c

35kd-Ag [pspA]

270

conserved 35 kDa Alanine-rich protein [phage-shock protein IM30]

7

8

 

Rv3875

esxA

95

6 kDA early secretory antigenic target ESXA (ESAT-6)

6

11

 

Rv1926c

mpt63

159

immunogenic protein MPT63 (16 kDa immunoprotective extracellular protein)

6

10

 

Rv2030c

 

681

hypothetical protein [putative esterase/transferase]

6

10

 

Rv3132c

devs

578

two component sensor histidine kinase DEVS

6

10

 

Rv3347c

PPE55

3157

PPE family protein (PE55) [8 copies pentapeptide repeats]

6

10

 

Rv0467

icl

428

isocitrate lyase(icl) [AceA]

6

9

 

Rv1130

[prpD]

526

hypothetical protein [2 methyl-citrate dehydratase]

6

9

 

Rv1169c

PE11

100

PE family protein (PE11) [triacyl glycerole lipase]

6

9

 

Rv1793

esxN

94

putative ESAT-6-like protein ESXN (ESAT-6-like protein 5)

6

9

 

Rv2629

 

374

hypothetical protein [peptide release factor erF1]

6

9

  1. The antigens are sorted by the qualitative score (Qual Total) and subsequently by the quantitative score (Quant Total) (see text). Group I includes all antigens with a qualitative score 8 and above, provided that the quantitative score is not lower than 12. The rest of the antigens having a qualitative score of 8 and those having a qualitative score of 7 and a quantitative score not lower than 9 were clustered into Group II. Group III included antigens with qualitative scores of 7 (and quantitative score of 8) and 6 (with a quantitative scores 9 and up). (a) The Gene name and annotation are based on the data deposited at the NCBI, [GenBank: AL123456]. In square brackets: updated gene name and/or annotation, resulting from the analyses conducted in this study.
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BMC Medical Genomics

ISSN: 1755-8794

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