Figure 2

DNA methylation profiles of the MHC. For each of the four samples tested (CD8⁺ lymphocytes, liver, placenta, sperm), the log₂ signal ratios (MeDIP/input) were uploaded as individual tracks to the UCSC genome browser using the 'smooth' function. Regions enriched or depleted in DNA methylation are shaded in black and grey, respectively. Also shown are the locations of HEP amplicons [49] and a track of the C+G content (the darker the shading, the higher the C+G content). For orientation, the approximate positions of the MHC class I, II and II sub-regions and some landmark genes are indicated.