Example of tDMRs correlating with tissue-specific gene expression. a) tDMRs within the region encoding the C4A and C4B genes. Vertical axis shows the log2 ratio of the two corresponding methylation profiles. Grey lines indicate regions (average size 2 kb) that are less methylated in liver compared to the other samples (placenta, sperm, CD8). Known genes and Affy_U95 expression array probes within this region are also shown. b). Expression of C4A and C4B. Graph shows the mean expression values of the probe corresponding to C4A and C4B (Affy_ID: 40776_at) transcripts in three samples tested: CD8, liver, placenta. C4A and C4B transcripts are highly expressed in liver tissue only. Data were taken from the GNF SymAtlas .