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Table 4 Results of pathway profiling using Pathway Express.

From: Microarray analysis in B cells among siblings with/without MS - role for transcription factor TCF2

Rank Database Name Pathway Name Impact Factor #Genes in Pathway #Input Genes in Pathway #Pathway Genes on Chip %Input Genes in Pathway %Pathway Genes in Input p-value
1 KEGG Cell adhesion molecules (CAMs) 6.94 132 11 126 2.099 8.333 9.69E-04
2 KEGG Axon guidance 6.94 130 11 126 2.099 8.462 9.69E-04
3 KEGG Leukocyte transendothelial migration 5.288 117 9 113 1.718 7.692 0.005054
4 KEGG Type I diabetes mellitus 5.232 44 5 40 0.954 11.364 0.005344
5 KEGG Regulation of actin cytoskeleton 4.461 206 12 198 2.29 5.825 0.011556
6 KEGG Natural killer cell mediated cytotoxicity 4.11 128 8 114 1.527 6.25 0.016401
7 KEGG Focal adhesion 3.949 194 11 188 2.099 5.67 0.019276
8 KEGG Tight junction 3.187 119 7 112 1.336 5.882 0.041314
9 KEGG Antigen processing and presentation 3.112 86 5 68 0.954 5.814 0.044499
10 KEGG Adherens junction 2.721 77 5 76 0.954 6.494 0.065823
11 KEGG Colorectal cancer 2.676 77 5 77 0.954 6.494 0.068828
12 KEGG Circadian rhythm 2.386 18 2 18 0.382 11.111 0.091979
13 KEGG Maturity onset diabetes of the young 1.975 25 2 23 0.382 8 0.138816
14 KEGG VEGF signaling pathway 1.972 72 4 70 0.763 5.556 0.139208
15 KEGG Fc epsilon RI signaling pathway 1.83 75 4 74 0.763 5.333 0.160493
16 KEGG mTOR signaling pathway 1.811 49 3 49 0.573 6.122 0.16353
17 KEGG Huntington's disease 1.558 30 2 30 0.382 6.667 0.210455
18 KEGG Wnt signaling pathway 1.474 147 6 144 1.145 4.082 0.229071
19 KEGG MAPK signaling pathway 1.441 273 10 268 1.908 3.663 0.236637
20 KEGG Toll-like receptor signaling pathway 1.416 91 4 88 0.763 4.396 0.242667
21 KEGG B cell receptor signaling pathway 1.318 63 3 63 0.573 4.762 0.267565
22 KEGG T cell receptor signaling pathway 1.294 93 4 93 0.763 4.301 0.274064
23 KEGG Long-term potentiation 1.235 67 3 66 0.573 4.478 0.290928
24 KEGG Insulin signaling pathway 1.143 135 5 131 0.954 3.704 0.318761
25 KEGG Type II diabetes mellitus 1.117 44 2 41 0.382 4.545 0.327167
26 KEGG Dentatorubropallidoluysian atrophy (DRPLA) 1.044 15 1 15 0.191 6.667 0.352194
27 KEGG Epithelial cell signaling in Helicobacter pylori infection 0.997 46 2 45 0.382 4.348 0.368822
28 KEGG Parkinson's disease 0.992 16 1 16 0.191 6.25 0.370684
29 KEGG Cytokine-cytokine receptor interaction 0.963 256 8 241 1.527 3.125 0.381922
30 KEGG Jak-STAT signaling pathway 0.936 153 5 144 0.954 3.268 0.392344
31 KEGG Apoptosis 0.86 84 3 83 0.573 3.571 0.423249
32 KEGG Complement and coagulation cascades 0.6 69 2 64 0.382 2.899 0.548544
33 KEGG Olfactory transduction 0.523 31 1 31 0.191 3.226 0.592482
34 KEGG SNARE interactions in vesicular transport 0.468 36 1 34 0.191 2.778 0.62642
35 KEGG Phosphatidylinositol signaling system 0.421 79 2 78 0.382 2.532 0.656227
36 KEGG Taste transduction 0.317 53 1 45 0.191 1.887 0.728441
37 KEGG GnRH signaling pathway 0.277 97 2 95 0.382 2.062 0.758254
38 KEGG Gap junction 0.27 99 2 96 0.382 2.02 0.763352
39 KEGG Adipocytokine signaling pathway 0.145 69 1 69 0.191 1.449 0.864684
40 KEGG Long-term depression 0.124 75 1 74 0.191 1.333 0.882976
41 KEGG Neuroactive ligand-receptor interaction 0.102 302 5 279 0.954 1.656 0.902917
42 KEGG ECM-receptor interaction 0.086 87 1 86 0.191 1.149 0.91743
43 KEGG Cell cycle 0.042 112 1 110 0.191 0.893 0.958921
44 KEGG Calcium signaling pathway 0.041 176 2 173 0.382 1.136 0.959904