BMC Medical Genomics

Table 2 Renal haemodynamics by genotypes for each ABCB1 variant in the Seychelles

From: Association of ABCB1genetic variants with renal function in Africans and in Caucasians

	*2677 G>T*			*3435 C>T*
	GG	GT	TT	CC	CT	TT
N	191	84	15	132	118	40
GFR^a (mL/min)	110 ± 32	126 ± 35	128 ± 29^b	110 ± 29	118 ± 37	128 ± 31^c
GFR^a (mL/min/1.73 m²)	103 ± 25	114 ± 26	118 ± 26^b	104 ± 24	107 ± 27	117 ± 25^c
ERPF^d (mL/min)	440 ± 143	488 ± 126	542 ± 109^b	434 ± 128	470 ± 150	513 ± 129^b
ERPF^d (mL/min/1.73 m²)	412 ± 119	445 ± 100	500 ± 102^b	413 ± 112	426 ± 117	470 ± 108^c
RVR^e (mm Hg/min/mL)	0.16 ± 0.06	0.13 ± 0.04	0.12 ± 0.04^b	0.16 ± 0.06	0.15 ± 0.06	0.13 ± 0.04^c
RVR^e (mm Hg/min/mL/1.73 m²)	0.15 ± 0.07	0.13 ± 0.04	0.11 ± 0.05^b	0.15 ± 0.07	0.14 ± 0.06	0.12 ± 0.04^c

Results are the unadjusted mean ± s.d. ^aGFR: glomerular filtration rate (inulin clearance). ^b P < 0.01, ^c 0.01 <P < 0.05, for linear trend across genotypes coded as 0 (GG or CC), 1 (GT or CT) and 2 (TT). ^dERPF: effective renal plasma flow (PAH clearance). ^eRVR: renal vascular resistance.

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ISSN: 1755-8794

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