Skip to main content

Advertisement

Table 2 Renal haemodynamics by genotypes for each ABCB1 variant in the Seychelles

From: Association of ABCB1genetic variants with renal function in Africans and in Caucasians

  2677 G>T 3435 C>T
  GG GT TT CC CT TT
N 191 84 15 132 118 40
GFRa (mL/min) 110 ± 32 126 ± 35 128 ± 29b 110 ± 29 118 ± 37 128 ± 31c
GFRa (mL/min/1.73 m2) 103 ± 25 114 ± 26 118 ± 26b 104 ± 24 107 ± 27 117 ± 25c
ERPFd (mL/min) 440 ± 143 488 ± 126 542 ± 109b 434 ± 128 470 ± 150 513 ± 129b
ERPFd (mL/min/1.73 m2) 412 ± 119 445 ± 100 500 ± 102b 413 ± 112 426 ± 117 470 ± 108c
RVRe (mm Hg/min/mL) 0.16 ± 0.06 0.13 ± 0.04 0.12 ± 0.04b 0.16 ± 0.06 0.15 ± 0.06 0.13 ± 0.04c
RVRe (mm Hg/min/mL/1.73 m2) 0.15 ± 0.07 0.13 ± 0.04 0.11 ± 0.05b 0.15 ± 0.07 0.14 ± 0.06 0.12 ± 0.04c
  1. Results are the unadjusted mean ± s.d. aGFR: glomerular filtration rate (inulin clearance). b P < 0.01, c 0.01 <P < 0.05, for linear trend across genotypes coded as 0 (GG or CC), 1 (GT or CT) and 2 (TT). dERPF: effective renal plasma flow (PAH clearance). eRVR: renal vascular resistance.