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Table 3 Association between the 2677T and 3435T ABCB1 alleles and renal haemodynamics in the Seychelles.

From: Association of ABCB1genetic variants with renal function in Africans and in Caucasians

  

Dependent variable

  

GFR (mL/min)

ERPF (mL/min)

RVR (mm Hg/mL/min)

Allele

Model

Coeff

SE

P value

Coeff

SE

P value

Coeff

SE

P value

2677T

Model 1

9.8

3.5

0.005

37.7

14.3

0.008

-0.015

0.005

0.003

 

Model 2

10.6

2.9

0.0002

47.5

11.6

0.00004

-0.016

0.004

0.0002

3435T

Model 1

6.1

2.7

0.03

29.5

11.4

0.009

-0.011

0.004

0.006

 

Model 2

4.4

2.3

0.06

28.1

10.5

0.007

-0.011

0.004

0.004

  1. Coeff: regression coefficient. SE: standard error. This table presents 3 * 4 different models, 4 for each dependent variable. Models 1 have age and sex as covariates, in addition to either the 2677T or the 3435T allele. Models 2 have age, sex, mean arterial blood pressure, diabetes mellitus, fasting blood glucose, body mass index, 24-h urine Na and K excretion (in mmol/24-h) as covariates. An additive mode of action was used for the T allele. All models are adjusted for ascertainment. Mean arterial pressure was not added as a covariate for RVR models.