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Table 3 Association between the 2677T and 3435T ABCB1 alleles and renal haemodynamics in the Seychelles.

From: Association of ABCB1genetic variants with renal function in Africans and in Caucasians

   Dependent variable
   GFR (mL/min) ERPF (mL/min) RVR (mm Hg/mL/min)
Allele Model Coeff SE P value Coeff SE P value Coeff SE P value
2677T Model 1 9.8 3.5 0.005 37.7 14.3 0.008 -0.015 0.005 0.003
  Model 2 10.6 2.9 0.0002 47.5 11.6 0.00004 -0.016 0.004 0.0002
3435T Model 1 6.1 2.7 0.03 29.5 11.4 0.009 -0.011 0.004 0.006
  Model 2 4.4 2.3 0.06 28.1 10.5 0.007 -0.011 0.004 0.004
  1. Coeff: regression coefficient. SE: standard error. This table presents 3 * 4 different models, 4 for each dependent variable. Models 1 have age and sex as covariates, in addition to either the 2677T or the 3435T allele. Models 2 have age, sex, mean arterial blood pressure, diabetes mellitus, fasting blood glucose, body mass index, 24-h urine Na and K excretion (in mmol/24-h) as covariates. An additive mode of action was used for the T allele. All models are adjusted for ascertainment. Mean arterial pressure was not added as a covariate for RVR models.