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Table 2 Regions of homozygous deletions identified by SNP array in this series.

From: Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma

CHR

CYTOBAND

Deletion START

Deletion END

No OF T WITHOUT EGFR MUT

No OF T WITH EGFR MUT

KNOWN GENES WITHIN REGIONS

GENES

  

2

2q36.3

227428860

228480608

0

2(1LOH+1HOMO)

3

RHBDD1

COL4A4

COL4A3

9

9p21.1

21701815

22685593

2 (LOH)

7(4LOH+3HOMO)

3

CDKN2A/2B

MTAP

DMRTA1

12

12q13.13

49778776

50467951

1(LOH)

1HOMO

3

TFCP2

POU6F1

DAZAP2

18

18q12.1

25534701

27580619

2(LOH)

3(2LOH+1HOMO)

3

CDH2

DSC3

DSG2

18

18q21.2

46939466

49883403

2(LOH)

4(3LOH+1HOMO)

2

RKHD2

DCC

 
  1. Homozygous deletion were validated by real time quantitative PCR for CDKN2A, DCC, DSC3 and DSG2.