Skip to main content

Advertisement

Table 3 Describes the population studied in terms of clinico-pathological features, gene mutations (EGFR, ERBB2, PIK3CA, KRAS, BRAF and TP53) as well as gene copy number (CCND1, CCNE1 and CDKN2A) analyzed by real time PCR.

From: Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma

Sex Age at diagnosis Smoker TNM Tumor Type EGFR TP53 KRAS ERBB2 PIK3CA STK11 CCND (2*2-DDCt) CCNE1 (2*2-DDCt) CDKN2A (2*2-DDCt)
2 F 49 Yes T2N0 BAC 0 0 0 0 0 c650insG, pFs265X 2,42 2.32 0.53
3 F 61 Yes T3N2 ADC 0 0 0 0 0 0 2,70 2.30 0.82
4 F 42 Yes T1N0 ADC 0 C743G>T, pR248L c34G>T pG12C 0 0 0 1,86 3.38 1.03
5 F 80 No T4N2 ADC 0 0 0 0 0 0 1,82 2.05 0.90
6 F 41 Yes T2N2 LCC 0 c358A>T, pK120X 0 0 0 0 3,16 2.19 2.38
7 F 39 Yes T2Nx LCC 0 c796G>T, pL266X 0 0 0 c153delG, pFs63X 3,13 2.36 3.42
8 F 69 No T2N0 ADC/BAC 0 0 0 0 0 0 2.68 2.36 0.71
9 F 65 No T2N1 ADC 0 c452454del, FsP153G 0 0 0 0 1.92 2.44 1.17
10 F 79 No T4N0 ADC/BAC L858R 0 0 0 0 0 2.68 2.92 0.33
12 F 52 Yes T2N0 ADC/BAC 0 0 c35G>A pG12D 0 0 C508C>T, pQ170X 1.71 1.43 1.05
13 F 77 No T2N0 ADC 0 0 0 0 0 0 2.28 2.26 1.22
15 F 73 Yes T2N0 BAC 0 0 c35G>T pG12V 0 0 0 1.75 2.16 0.72
16 F 46 Yes T2N0 ADC 0 c614A>G, pY205C 0 0 0 0 4.59 2.66 1.90
17 F 84 No T2N0 ADC/BAC L858R 0 0 0 0 0 1.84 1.97 0.90
18 F 65 No T2N0 ADC/BAC c2241_2258del p747-753del insQ747 c880delG, FsE294S 0 0 0 0 2.22 2.51 2.18
21 F 50 Yes T2N0 ADC/BAC 0 0 c34G>T pG12C 0 0 0 2.15 2.75 1.73
22 F 78 Yes T2N1 LCC 0 0 0 0 0 c595G>C, pE198Q 4.64 3.05 1.23
23 F 49 Yes T2N0 LCC 0 0 0 0 0 c1072C>Q, pF354L 2.90 2.37 0.96
24 F 65 Yes T2N0 BAC 0 c574C>T, PQ192X c34G>T pG12C 0 0 0 1.82 2.34 1.77
25 F 55 No T2N0 ADC/BAC 0 0 0 0 0 0 1.84 1.81 1.51
26 F 73 No T2N2 ADC 0 c783-2A>G, SLPICEMUT 0 c2322_2323ins12, pM774_A775ins AYVM 0 0 2.60 3.56 1.68
29 F 61 No T2N1 ADC L858R 0 0 0 0 0 1.98 2.06 0.29
30 F 59 No T4N2 ADC L858R c258-280del, FsA86A 0 0 0 0 2.31 1.47 0.59
31 F 75 No T2N2 ADC c2240_2257del, p747-753del insS747 0 0 0 0 0 2.08 2.31 1.02
32 F 68 Yes T2N0 ADC 0 c848G>C, pR283P 0 0 0 0 4.44 3.52 1.75
34 F 59 Yes T2N2 SCC 0 0 0 0 0 0 5.62 2.21 1.31
36 F 70 No T2N0 ADC 0 0 0 0 0 0 2.87 2.24 1.21
37 F 72 Yes T1NO SCC 0 0 0 0 0 0 2.17 2.00 1.62
38 F 60 Yes T2N2 ADC 0 c747G>T, pR249S c34G>T pG12C 0 0 0 2.41 2.48 0.81
39 F 75 No T2N0 ADC/BAC L858R c189G>T, pE62X 0 0 0 0 0.91 2.04 0.92
41 F 56 No T1NO ADC/BAC L858R 0 0 0 0 0 2.58 3.08 1.29
42 F 43 Yes T2N0 ADC 0 0 c35G>T pG12V 0 0 c580G>T, pD194Y 1.84 2.49 1.01
43 F 72 No T2N0 ADC c2310insAGCGTGGAC p770insSVD 0 0 0 0 0 2.11 2.41 0.57
44 F 63 Yes T2N0 LCC 0 c743G>T, pR248L 0 0 0 0 2.38 10.31 0.74
45 F 60 Yes T2N0 ADC/BAC 0 c166G>T, pE56X 0 0 0 0 2.73 2.94 1.03
46 F 57 Yes T2N0 ADC 0 0 0 0 0 0 2.39 2.67 0.70
48 F 49 Yes T3N0 ADC 0 0 0 0 0 0 2.58 2.98 0.83
49 F 75 No T2N0 BAC c2237_2255delinsT, p746-752del insV746 0 0 0 0 0 1.77 2.20 1.58
50 F 42 Yes T3N0 LCC 0 c814G>T, pV272L 0 0 0 0 6.26 3.13 2.40
51 F 51 Yes n.d. SCC 0 0 0 0 0 0 3.52 3.18 1.58
52 F 78 No T2N2 ADC 0 0 0 0 0 0 1.77 2.13 1.79
53 F 55 Yes T4NO ADC/BAC 0 0 c34G>T pG12C 0 0 0 1.79 2.14 2.06
54 F 78 No T2N0 ADC/BAC c2239_2251delinsC, p747-751delinsP747 0 0 0 0 0 1.31 2.12 1.90
55 F 72 No T2N2 ADC/BAC L858R COMPLEX INSDEL 0 0 0 0 1.65 1.81 1.72
57 M 85 Yes T2N0 ADC 0 0 0 0 0 0 1.87 1.94 1.89
58 M 51 Yes T2N0 ADC 0 c467G>C, pR156P 0 0 0 0 2.79 1.96 1.77
59 M 51 Yes T2N0 ADC 0 0 c34G>T pG12C 0 0 0 2.10 1.39 1.92
60 M 71 Yes T1NO SCC 0 c-15-96del, Fs mutation 0 0 0 0 1.85 1.78 1.88
62 M 48 Yes T4NO ADC 0 C783-2A>G, SLPICEMUT 0 0 0 0 2.80 2.26 1.73
64 M 71 Yes T3N1 ADC 0 c466-483del, FsI162H 0 0 0 0 2.86 2.12 0.69
65 M 49 Yes T4NO ADC/BAC 0 C817C>T, pR273C 0 0 0 0 2.33 2.24 2.02
66 M 56 Yes T2N1 ADC 0 0 0 0 0 0 1.88 1.98 1.82
67 M 56 Yes n.d. ADC 0 0 c34G>T pG12C 0 0 0 3.25 2.84 1.93
68 M 58 Yes T2N0 ADC 0 c818G>T, pR273L c34G>T pG12C 0 0 0 3.26 1.86 1.44
69 M 72 Yes T3N0 ADC 0 c610G>T, pE204X 0 0 0 0 3.17 1.55 2.19
70 M 71 Yes T3N0   0 0 0 0 0 0 2.13 1.74 1.90
71 M 69 Yes T3N1 ADC 0 C528C>G, pC176W 0 0 0 0 2.68 1.59 1.97
72 M 77 Yes T3N2 SCC 0 c408DELA, FsQ136H 0 0 0 0 2.67 2.23 1.61
74 M 76 Yes T2N0 SCC 0 c318G>C, pG105R 0 0 0 0 3.28 3.94 2.11
75 M 59 Yes T3N2 SCC 0 c797delG, FsG266D 0 0 0 0 4.66 2.74 1.44
76 M 48 Yes T3N0 ADC 0 0 c35G>T pG12V 0 0 0 2.32 2.92 1.90
78 M 67 Yes T2N0 SCC 0 0 0 0 0 0 2.42 1.81 1.75
79 M 57 Yes T2N0 ADC 0 c818G>T, pR273L c34G>T pG12C 0 0 0 4.27 5.76 1.69
80 M 58 Yes T1N2 ADC 0 0 c35G>A pG12D 0 0 0 6.36 1.66 1.47
82 M 62 Yes T2N1 SCC 0 0 0 0 0 0 2.24 1.88 1.84
83 M 51 Yes T3N0 ADC 0 C139-140DEL, pFsP47G c844C>T, pR282W c34G>C pG12R 0 0 C521A>G, pM174R 1.87 2.38 1.98
84 M 67 Yes T4N2 SCC 0 0 0 0 0 0 2.49 2.19 1.98
85 M 56 Yes T2N0 ADC 0 C577C>G, pH193D 0 0 0 0 2.53 2.56 2.09
86 M 74 Yes T1NO SCC 0 0 0 0 0 0 2.19 2.04 1.84
87 M 52 Yes T2N1 ADC 0 c595G>T, pG199X 0 0 0 c126-149del, pFsmutation 2.38 2.61 1.98
88 M 75 Yes T4N1 SCC 0 C586C>T, pR196X 0 0 c1633G>A, pE545K 0 2.88 3.89 0.28
89 M 83 Yes T4N1 SCC 0 c560-lG>T, SPLICEMUT 0 0 0 0 2.37 1.77 1.73
92 M 83 Yes T2N0 SCC 0 0 0 0 0 0 1.31 0.66 1.86
93 M 50 No T2N0 ADC 0 n.d. 0 0 0 0 3.81 1.44 1.72
94 M 73 Yes T3N2 SCC 0 c785G>T, pG262V 0 0 0 0 1.40 1.53 1.31
95 M 64 Yes T2N1 SCC 0 0 0 0 0 0 2.40 2.28 1.92
96 M 67 Yes T2N2 SCC 0 c438G>A, pW146X 0 0 0 0 4.16 2.87 1.71
97 M 81 Yes T4N2 ADC 0 0 0 0 0 0 7.44 2.68 1.64
98 M 57 Yes T2N0 ADC 0 0 0 0 0 0 2.41 2.16 2.13
99 M 69 Yes T2N1 SCC 0 C586C>T, pR196X 0 0 0 0 2.85 6.96 1.14
100 M 74 Yes T3N2 SCC 0 0 0 0 0 0 2.69 2.42 1.73
101 M 51 No T4N2 ADC 0 0 0 0 0 0 2.44 1.95 1.9
102 M 61 Yes T2N0 SCC 0 c578A>G, pH193R 0 0 0 0 6.13 1.94 1.89
103 M 52 Yes T2N0 ADC 0 0 0 0 0 0 2.42 1.34 1.87
104 M 75 Yes T2N0 ADC 0 0 0 0 0 0 1.38 1.35 2.18
105 M 71 Yes T2N0 ADC 0 C832DELC, pFsP278L 0 0 0 0 5.13 2.04 1.75
106 M 56 Yes n.d. SCC 0 C906DELG, pFsS303A 0 0 0 0 2.66 2.87 1.71
107 M 54 Yes T1NO ADC 0 c460G>A, pG154I c34G>T pG12C 0 0 0 2.50 0.81 0.55
108 M 57 Yes T3N1 SCC P753L C902DELC, pFsP301Q 0 0 0 0 6.91 1.55 1.09
109 M 52 Yes T2N0 ADC 0 0 c34G>T pG12C 0 0 0 1.48 1.79 1.65
110 M 75 Yes T1N1 SCC 0 0 0 0 0 0 3.11 1.71 1.97
111 M 65 Yes T2N2 ADC 0 0 0 0 0 0 1.41 1.58 2.00
112 M 51 Yes T1NO ADC 0 0 c34G>T pG12C c35G>T pG12V 0 0 0 2.65 2.73 1.49
134 F 62 No T2N0 ADC L858R c503A>T, pH168L 0 0 0 0 2.00 13.47 2.13
135 F 72 No T1NO BAC c2237_2255delinsT, p746-752del insV746 0 0 0 0 0 1.31 1.16 0.46
143 F 55 Yes T2N0 ADC/BAC 0 0 c34G>T pG12C 0 0 0 1.99 2.10 1.83
177 F 67 Yes T2N0 ADC/BAC 0 0 c35G>A pG12D 0 0 0 2.00 1.94 1.71
246 F 44 Yes T2N2 ADC 0 0 c34G>T pG12C 0 0 0 2.25 2.59 1.78
  1. For quantitative PCR, an inferred copy number ≥ 4 defines an amplification of target and an inferred copy number ≤ 0.6 defines homozygous deletion. Tumors analyzed by Xba1 50000 SNPs array (Affymetrix) are underlined.