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Table 4 Statistical analysis: CCND1, CCNE1, CDKN2A associations with clinico-pathological features and other gene alterations.
| CDKN2A | CDKN2A presence of homozygous deletion n (%) | CDKN2A absence of homozygous deletion n (%) | p | |
|---|---|---|---|---|
| Age | 62 | 62,6 | NS | |
| Gender | Women | 6 (12) | 44 (88) | 0,157 |
| Men | 2 (4) | 46 (96) | ||
| Histology | ADC | 7 (10) | 61 (90) | 0,483 |
| LCC | 0 (0) | 6 (100) | ||
| SCC | 1 (4) | 23 (96) | ||
| Tobacco | Never-smoker | 5 (20) | 20 (80) | 0,012 |
| Smoker | 3 (4) | 70 (96) | ||
| Mutated | 5 (33) | 10 (67) | ||
| EGFR | Non-mutated | 3 (4) | 80 (96) | 0,002 |
| Mutated | 1 (5) | 19 (95) | ||
| KRAS | Non-mutated | 7 (9) | 71 (91) | 0,563 |
| Mutated | 1 (14) | 6 (86) | ||
| STK11 | Non-mutated | 7 (8) | 84 (92) | 0,46 |
| Mutated | 3 (7) | 40 (93) | ||
| TP53 | Non-mutated | 5 (9) | 50 (91) | 0,704 |
| AKT-mTOR activation* | Yes | 7 (29) | 17 (71) | <0,001 |
| No | 1 (1) | 73 (99) | ||
| CCND1 | Amplification n (%) | No amplification n (%) | P | |
| Age | 61,8 | 63 | NS | |
| Gender | Women | 5 (10) | 45 (90) | 0,331 |
| Men | 8 (17) | 40 (83) | ||
| Histology | ADC | 6 (9) | 62 (91) | 0,079 |
| LCC | 2 (33) | 4 (67) | ||
| SCC | 5 (21) | 19 (71) | ||
| Tobacco | Never-smoker | 0 | 25 (100) | 0,023 |
| Smoker | 13 (18) | 60 (82) | ||
| EGFR | Mutated | 1 (7) | 14 (93) | 0,331 |
| Non-mutated | 12 (14) | 71 (86) | ||
| KRAS | Mutated | 2 (10) | 18 (90) | 0,629 |
| Non-mutated | 11 (14) | 67 (86) | ||
| STK11 | Mutated | 1 (1) | 6 (99) | 0,934 |
| Non-mutated | 12 (13) | 79 (87) | ||
| TP53 | Mutated | 9 (21) | 34 (79) | 0,048 |
| Non-mutated | 4 (7) | 51 (83) | ||
| AKT-mTOR activation* | Yes | 2 (8) | 22 (92) | 0,412 |
| No | 11 (15) | 63 (85) | ||
| CCNE1 | Amplification n (%) | No-amplification n (%) | P | |
| Age | 67 | 62,5 | NS | |
| Gender | Women | 2 (4) | 47 (96) | 0,371 |
| Men | 4 (8) | 45 (92) | ||
| Histology | ADC | 2 (3) | 66 (97) | 0,099 |
| LCC | 1 (1) | 5 (99) | ||
| SCC | 3 (13) | 21 (87) | ||
| Tobacco | Never-smoker | 1 (1) | 24 (99) | 0,518 |
| Smoker | 5 (17) | 68 (83) | ||
| EGFR | Mutated | 1 (1) | 14 (99) | 0,924 |
| Non-mutated | 5 (7) | 78 (93) | ||
| KRAS | Mutated | 1 (1) | 19 (99) | 0,814 |
| Non-mutated | 5 (6) | 73 (94) | ||
| STK11 | Mutated | 0 | 7 (100) | 0,483 |
| Non-mutated | 6 (7) | 85 (93) | ||
| TP53 | Mutated | 6 (15) | 37 (85) | 0,006 |
| Non-mutated | 0 | 55 (100) | ||
| AKT-mTOR activation* | Yes | 2 (8) | 22 (82) | 0,603 |
| No | 4 (5) | 70 (85) | ||
