Figure 1

Microarray analysis. A. Differences in RNA expression 1 or 3 months after STZ induced diabetes were analyzed by Codelink whole genome microarray. After filtering for genes detected as present, differential expression was determined by ANOVA p < 0.01 and a fold change of 1.2 fold or greater. For differentially expressed genes values for each of the five animals in control and STZ treated groups are given in log scale normalized as described in the Methods. Lines are colored according to their relative normalized expression level. Far more changes and larger magnitude changes were detected after 3 months of STZ-induced diabetes as opposed to 1 month. B. Set analysis of the changes at 1 month and 3 months of STZ-induced diabetes demonstrates that the vast majority of 3 month changes are not observed at 1 month of STZ-induced diabetes.