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Table 4 Enriched pathways of estrogen regulated genes in human and rat

From: Molecular analysis of the vaginal response to estrogens in the ovariectomized rat and postmenopausal woman

Gene Set Rat T1* Human T1*
Cholesterol_Biosynthesis // Genmapp 6.55 3.91
Cellular Lipid Metabolism // GO:0044255 2.21 3.67
Mitotic Cell Cycle // GO:0000278 2.8 3.14
Cysteine Protease Inhibitor Activity // GO:0004869 2.94 3.02
Small Protein Conjugating Enzyme Activity // GO:0008639 2.34 2.85
Epidermis Development // GO:0008544 5.44 2.65
Steroid Metabolism // GO:0008202 3.23 2.65
Ubiquitin Conjugating Enzyme Activity // GO:0004840 2.3 2.55
Tgf_Beta_Signaling_Pathway: Biocarta -3.09 -2.54
Complement_Activation_Classical -2.29 -2.57
Chr3Q13: Cytogenetic Band -2.36 -2.6
Complement_Activation_Classical // GenMAPP -2.43 -2.63
TGF_Beta_Signaling_Pathway // GenMAPP -2.93 -2.64
Matrix_Metalloproteinases // GenMAPP -3.06 -2.65
Complement Activation, Classical Pathway // GO:0006958 -2.28 -2.67
Cell Differentiation // GO:0030154 -2.39 -2.71
GLUT_UP: Peng_at_al_2002 -3.26 -2.73
chr1q24: Cytogenetic band -2.87 -2.89
Matrix_Metalloproteinases: BioCarta -2.52 -2.95
RAP_UP: Peng_at_al_2002 -3.46 -2.99
Locomotory Behavior // GO:0007626 -2.28 -3.14
Transmembrane Receptor Protein Tyrosine Kinase Activity // GO:0004714 -2.66 -3.16
EMT_UP: Jechlinger_et_al_2003 -3.18 -3.21
Specific Rna Polymerase Ii Transcription Factor Activity // GO:0003704 -3.01 -3.24
RAR_UP: Manually Curated -3.08 -3.25
Response To Wounding // GO:0009611 -2.48 -3.28
Cell Motility // GO:0006928 -2.73 -3.29
Locomotion // GO:0040011 -2.7 -3.33
cell_adhesion -2.32 -3.34
classic complement pathway -2.77 -3.34
Vascular Endothelial Growth Factor Receptor Activity // GO:0005021 -2.56 -3.38
Transmembrane Receptor Protein Kinase Activity // GO:0019199 -3.09 -3.48
Immune Complement Pathway -3.25 -3.66
STTTCRNTTT: IRF:Interferon regulatory factor -3.55 -3.7
CR_IMMUNE_FUNCTION: PNAS_2009 -3.29 -3.72
Response To Virus // GO:0009615 -2.65 -3.85
Cell Adhesion // GO:0007155 -5.01 -4.05
Humoral Defense Mechanism // GO:0016064 -2.75 -4.37
Humoral Immune Response // GO:0006959 -2.93 -4.42
Antigen Processing // GO:0030333 -3.72 -4.49
morf1_34033_s_at_LILRB1: na -3.27 -4.66
Antigen Presentation // GO:0019882 -3.98 -5.87
Response To External Biotic Stimulus // GO:0043207 -2.73 -5.95
Response To Pest, Pathogen Or Parasite // GO:0009613 -2.87 -6.21
Immune Response // GO:0006955 -3.61 -6.49
  1. T1* Score of differential expression (NT_k statistic as described in Tian et al[20].)