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Table 4 Enriched pathways of estrogen regulated genes in human and rat

From: Molecular analysis of the vaginal response to estrogens in the ovariectomized rat and postmenopausal woman

Gene Set

Rat T1*

Human T1*

Cholesterol_Biosynthesis // Genmapp

6.55

3.91

Cellular Lipid Metabolism // GO:0044255

2.21

3.67

Mitotic Cell Cycle // GO:0000278

2.8

3.14

Cysteine Protease Inhibitor Activity // GO:0004869

2.94

3.02

Small Protein Conjugating Enzyme Activity // GO:0008639

2.34

2.85

Epidermis Development // GO:0008544

5.44

2.65

Steroid Metabolism // GO:0008202

3.23

2.65

Ubiquitin Conjugating Enzyme Activity // GO:0004840

2.3

2.55

Tgf_Beta_Signaling_Pathway: Biocarta

-3.09

-2.54

Complement_Activation_Classical

-2.29

-2.57

Chr3Q13: Cytogenetic Band

-2.36

-2.6

Complement_Activation_Classical // GenMAPP

-2.43

-2.63

TGF_Beta_Signaling_Pathway // GenMAPP

-2.93

-2.64

Matrix_Metalloproteinases // GenMAPP

-3.06

-2.65

Complement Activation, Classical Pathway // GO:0006958

-2.28

-2.67

Cell Differentiation // GO:0030154

-2.39

-2.71

GLUT_UP: Peng_at_al_2002

-3.26

-2.73

chr1q24: Cytogenetic band

-2.87

-2.89

Matrix_Metalloproteinases: BioCarta

-2.52

-2.95

RAP_UP: Peng_at_al_2002

-3.46

-2.99

Locomotory Behavior // GO:0007626

-2.28

-3.14

Transmembrane Receptor Protein Tyrosine Kinase Activity // GO:0004714

-2.66

-3.16

EMT_UP: Jechlinger_et_al_2003

-3.18

-3.21

Specific Rna Polymerase Ii Transcription Factor Activity // GO:0003704

-3.01

-3.24

RAR_UP: Manually Curated

-3.08

-3.25

Response To Wounding // GO:0009611

-2.48

-3.28

Cell Motility // GO:0006928

-2.73

-3.29

Locomotion // GO:0040011

-2.7

-3.33

cell_adhesion

-2.32

-3.34

classic complement pathway

-2.77

-3.34

Vascular Endothelial Growth Factor Receptor Activity // GO:0005021

-2.56

-3.38

Transmembrane Receptor Protein Kinase Activity // GO:0019199

-3.09

-3.48

Immune Complement Pathway

-3.25

-3.66

STTTCRNTTT: IRF:Interferon regulatory factor

-3.55

-3.7

CR_IMMUNE_FUNCTION: PNAS_2009

-3.29

-3.72

Response To Virus // GO:0009615

-2.65

-3.85

Cell Adhesion // GO:0007155

-5.01

-4.05

Humoral Defense Mechanism // GO:0016064

-2.75

-4.37

Humoral Immune Response // GO:0006959

-2.93

-4.42

Antigen Processing // GO:0030333

-3.72

-4.49

morf1_34033_s_at_LILRB1: na

-3.27

-4.66

Antigen Presentation // GO:0019882

-3.98

-5.87

Response To External Biotic Stimulus // GO:0043207

-2.73

-5.95

Response To Pest, Pathogen Or Parasite // GO:0009613

-2.87

-6.21

Immune Response // GO:0006955

-3.61

-6.49

  1. T1* Score of differential expression (NT_k statistic as described in Tian et al[20].)