Skip to main content

Advertisement

Table 3 Eighteen common literature-defined oncogenic concepts (MCM) across the four breast cancer gene signatures (significance of overlap, P = 0.0002)

From: Pathway analysis reveals functional convergence of gene expression profiles in breast cancer

  70-gene profile Wound Response Intrinsic Subtype Meta-90   
Common GeneSet No. of mapped genes (Enrichment p-value**) MCM size Description
MCM258 7 (3e-04) 25 (2e-04) 19 (0.21) 6 (0.09) 350 Downregulated genes in prostate cancer cells in response to MSA (full list)
MCM458 2 (0.16) 24 (1e-04) 34 (0.005) 6 (0.24) 322 Differentially expressed genes in MCF7 cells expressing Myb
MCM396 10 (0.13) 89 (2e-04) 117 (0.005) 20 (0.21) 2265 Upregulated genes in U937 cells expressing the PLZF/RAR fusion protein
MCM691 1 (0.1) 6 (0.06) 19 (6e-04) 3 (0.16) 101 Up-regulated genes in untreated or permanently tamoxifen-treated MaCa 3366/TAM compared with MaCa 3366
MCM513 2 (0.22) 24 (6e-04) 29 (0.13) 12 (0.04) 375 Differentially expressed genes in EcR-293 cells in response to BRCA1 expression
MCM277 1 (0.01) 3 (0.02) 5 (0.05) 1 (0.16) 22 Upregulated genes in NCCIT cells in response to Wnt-3A
MCM30 1 (0.01) 4 (0.004) 3 (0.25) 1 (0.15) 24 Upregulated genes in colorectal cancer cells
MCM673 2 (0.01) 7 (0.008) 7 (0.28) 3 (0.15) 79 Androgen
MCM6209872 2 (0.003) 2 (0.13) 5 (0.09) 1 (0.16) 34 Skin
MCM349 1 (0.01) 2 (0.05) 2 (0.25) 2 (0.04) 23 Downregulated genes in hSNF5/INI1-deficient malignant rhabdoid tumor cell line upon hSNF5/INI1 expression
MCM12 2 (0.008) 2 (0.25) 7 (0.09) 2 (0.14) 56 Aniogenic and Non-angiogenic tumours Signature
MCM363 5 (0.13) 37 (0.007) 46 (0.28) 14 (0.15) 808 Upregulated genes in monocytes in response to IL-10 stimulation for 1 and 4 hours
MCM574 4 (0.04) 22 (0.03) 23 (0.27) 6 (0.13) 497 Upregulated genes in advanced papillary serous tumor specimens
MCM683 1 (0.1) 6 (0.06) 11 (0.06) 2 (0.17) 111 Downregulated genes wrt 3,5-diaryl-1,2,4-oxadiazole (MX-126374)
MCM379 1 (0.13) 7 (0.07) 12 (0.12) 2 (0.29) 129 Unique genes regulated by tamoxifen, but not estradiol in osteosarcoma cells
MCM1067 1 (0.05) 3 (0.15) 5 (0.27) 1 (0.21) 64 Upregulated genes in immmortilized epithelial cells in respense to Ad5-GFP infection
MCM375 1 (0.13) 6 (0.12) 10 (0.14) 2 (0.27) 127 Unique genes regulated by estradiol, but not raloxifene in osteosarcoma cells
MCM402 1 (0.11) 4 (0.25) 8 (0.28) 3 (0.14) 116 Downregulated genes in HepG2 T1 treated cells resulting from MIZ depletion
  1. **Hypergeometic test enrichment P-value adjusted for multiple testing.