Table 2 Name and function of the differentially expressed genes that best distinguish samples by TNF treatment variable
GENE | UniGene ID | GENE NAME | FUNCTION |
|---|---|---|---|
ADORA2b | Hs.167046 | adenosine A2b receptor | activation of MAPK |
AKAP1 | Hs.463506 | A kinase (PRKA) anchor protein 1 | RNA binding |
BTG2 | Hs.519162 | BTG family, member 2 | negative regulation of cell proliferation |
C3 | Hs.529053 | complement component 3 | inflammatory response |
CCL20 | Hs.75498 | chemokine (C-C motif) ligand 20 | inflammatory response |
CD44 | Hs.502328 | CD44 antigen | cell adhesion |
cig5 | Hs.17518 | radical S-adenosyl methionine domain containing 2 | Catalytic activity |
CLCA4 | Hs.546343 | chloride channel, calcium activated, family member 4 | chloride transport |
DC-UbP | Hs.179852 | dendritic cell-derived ubiquitin-like protein | Protein modification |
FAD104 | Hs.159430 | fibronectin type III domain containing 3B | cell differentiation |
FLJ21511 | Hs.479703 | FLJ21511 | Unknown function |
FMNL3 | Hs.179838 | formin-like 3 | cell organization and biogenesis |
GFPT2 | Hs.30332 | glutamine-fructose-6-phosphate transaminase 2 | carbohydrate biosynthesis |
HLA-F | Hs.519972 | major histocompatibility complex, class I, F | antigen presentation, endogenous antigen |
IL1F9 | Hs.211238 | interleukin 1 family, member 9 | inflammatory response |
INHBA | Hs.28792 | inhibin, beta A | cell cycle arrest, negative regulation of immune cell differentiation |
KIAA0303 | Hs.133539 | microtubule associated serine/threonine kinase family member 4 | protein kinase activity |
KIAA1279 | Hs.279580 | KIAA1279 | Unknown function |
LAP3 | Hs.479264 | leucine aminopeptidase 3 | Protein metabolism |
MARCKS | Hs.75061 | MARCKS-like 1 | calmodulin binding, macrophage activation |
MGAT4B | Hs.437277 | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B | cytokine activity |
MGC45400 | Hs.389734 | transcription elongation factor A (SII)-like 8 | translation elongation factor activity |
MMP9 | Hs.297413 | matrix metalloproteinase 9 | proteolysis and peptidolysis |
NFKBIA | Hs.81328 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | cytoplasmic sequestering of NF-kappaB |
NMES1 | Hs.112242 | normal mucosa of esophagus specific 1 | Unknown function |
OAS1 | Hs.524760 | 2',5'-oligoadenylate synthetase 1 | immune response to viral infections |
PLAU | Hs.77274 | plasminogen activator | chemotaxis |
RDH-E2 | Hs.170673 | epidermal retinal dehydrogenase 2 | oxidoreductase activity |
RFX5 | Hs.166891 | regulatory factor X, 5 | inflammatory response, HLA class II expression |
RIG-1 | Hs.17466 | retinoic acid receptor responder (tazarotene induced) 3 | negative regulation of cell proliferation |
RIPK2 | Hs.103755 | receptor-interacting serine-threonine kinase 2 | inflammatory response |
SASH1 | Hs.193133 | SAM and SH3 domain containing 1 | Negative regulation of cell cycle |
SDCBP | Hs.200804 | syndecan binding protein (syntenin) | intracellular signaling cascade, interleukin-5 receptor binding |
SEC24A | Hs.211612 | SEC24 related gene family, member A | intracellular protein transport |
SERPINB2 | Hs.514913 | encoding serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 | anti-apoptosis |
SF3B4 | Hs.412818 | myotubularin related protein 11 | RNA splicing |
SOD2 | Hs.487046 | superoxide dismutase 2 | age-dependent response to reactive oxygen species, cellular defense response |
TMSB4 | Hs.522584 | thymosin, beta 4, X-linked | cytoskeleton organization and biogenesis |
VMP1 | Hs.444569 | transmembrane protein 49 | Unknown function |