My sister's keeper?: genomic research and the identifiability of siblings

BMC Medical Genomics

Table 2 Finding the MAF that maximizes the log likelihood ratio test statistic for each Sib₂genotypic inference type.

Sib₂	Sib₁	Maximizing MAF	Log(Λ_{Ind1, Ind2 genotypes})
AA	AA	0.01	3.407
Aa	AA	0.01	3.699
aa	AA	0.01	3.389
AA	Aa	0.99	1.396
Aa	Aa	0.01, 0.99	1.407
aa	Aa	0.01	1.396
AA	aa	0.99	3.389
Aa	aa	0.99	3.699
aa	aa	0.99	3.407

The maximizing MAF is the allele population frequency at which the most information will be derived about the Sib₂ genotype from Sib₁ under that Sib genotypic combination. Note: There are two equally maximizing MAF values for Log(Λ_{Sib1Aa, Sib2Aa}), 0.01 and 0.99, both resulting in a value of 1.407.

ISSN: 1755-8794