Figure 3

Hierarchical cluster analysis of TOV-112D grown in different conditions. Hierarchical clustering of normalized chromosome 3 gene expression data sets derived from TOV-112D grown as monolayer culture (L), and the alternative growth conditions consisting of spheroid cultures (S), tumors derived from xenograft tumors from subcutaneous (TSC) or intraperitoneal (TIP) injection sites in nude mice, and monolayer cultures derived from these tumors (LSC and LIP). The analysis was carried out using R's cluster package with the Pearson correlation distance where the y-axis 'height' represents the 1 minus the correlation distance. Only part of the clustering analysis is shown which includes the distal branches where the highest degree of correlation begins to deviate for each growth condition (at around 96.5%).