A heatmap illustrating the distinct expression profiles of 49 NB primary tumours with varying ploidy status. Gene expression profiles visualized according to 51 differentially expressed genes [FDR < 0.05]. (Right) Gene dendrogram is divided in 2 main gene clusters. Top cluster: genes displaying higher expression in near-triploid tumours; a statistically significant proportion of genes map to chromosome 1 (p = 0.01) and chromosome 17 (p < 0.0001) (Blue). Bottom cluster: genes with higher expression in near-diploid/tetraploid NBTs. (Bottom) Filled in boxes: Ploidy: black = near-diploid, empty white boxes = near-triploid, grey = near-tetraploid NBTs; MYCN: black = amplified, white = not amplified; Age: black > 12 months, white < 12 months; INSS: black = Stage 4 NBTs, white = stages 1, 2, 3, and 4S.