Figure 4

FISH analysis. Intra-tumoural cell heterogeneity, cancer cells exhibit different alterations of chromosome 17. FISH analysis using probes for chromosome 17 (red, LSI p53; green, CEP 17) showing different cellular populations within the same NBT in terms of probe signal numbers. In the panels are reported two representative NBT cases; A. near-triploid NBT; B. near-diploid case. Five signal cells in this sample were very rare populations (< 5%) and are not displayed in Table 3.