Figure 4

Host gene expression level in primary tumors database. Expression levels of MEST, EVL, and GULP1, as assessed by DNA microarray analysis of a patient database including samples from 24 normal donors (N), 34 MGUS, 269 MM, and nine PCL. The scaled values on the vertical axis represent the fluorescence intensity of streptavidin-PE-stained biotinylated cRNA hybridized to specific probes set on HG-U133A arrays; the baseline was set at the cut-off value calculated as mean + 3STDEV in 24 normal samples. The samples are ordered and grouped on the horizontal axis. Samples above the cut-off level and analysed by Q-RT-PCR are coloured in red; for MEST, the gene expression value is also reported of the sample barely exceeding the cut-off and not analysed by Q-RT-PCR.