Skip to main content

Table 1 Most highly deregulated transcripts in mammary gland induced by bexarotene treatment on each transgenic mice mammary cancer model (Fold change ≥ 7; p < 0.01).

From: Transcriptomic signature of Bexarotene (Rexinoid LGD1069) on mammary gland from three transgenic mouse mammary cancer models

Tag Gene Description Entrez Gene Fold Change*
p53-null     
GTTTGCTGTA Serpinb6a Serine (or cysteine) peptidase inhibitor 20719 17.0
AGTCTCGAGG Slc1a5 Solute carrier family 1 20514 12.0
GGTTTGGGGG Jup Junction plakoglobin 16480 11.0
TGCGTGCTGG Timp2 Tissue inhibitor of metalloproteinase 2 21858 11.0
TTGAAATTAC BC061494 CDNA sequence 381832 11.0
GATTTCTTTG Gpc3 Glypican 3 14734 10.0
TAACCAAAAA Itgb4 Integrin beta 4 192897 10.0
CCCAGTCCCT Ltbp4 Latent transforming growth factor bindin. prot. 4 108075 8.0
GACTCTATAT Csn2 Casein beta 12991 -15.0
CAATAAAACA Sar1b SAR1 gene homolog B (S. Cerevisiae) 66397 -11.0
GCAGCGATTC Nme2 Expressed in non-metastatic cells 2 18103 -10.0
TGTTCTATGG Laptm5 Lysosomal-associated protein transmembrane 5 16792 -9.0
GTGTTTTGCT AI451557 Expressed sequence 102084 -9.0
CTAGGTGGTG Glycam1 Glycosylation dependent cell adhesion molecule 1 14663 -8.8
TAAAGTCAAT Muc15 Mucin15 269328 -8.0
TCAGAGTGAG Igh-6 Immunoglobulin heavy chain 6 16019 -7.5
MMTV-erbB2     
AGACCCTGTC Pnpla3 Patatin-like phospholipase domain containing 3 116939 44.0
TATGAGATAG Timm9 Translocase of inner mitochondrial membrane 9 30056 15.0
AGCCCTCGGA Acads Acyl-Coenzyme A dehydrogenase 11409 12.0
ACCGGGCTGG Elovl6 ELOVL family member 6 170439 12.0
TGACAGAAGA Tnnc2 Troponin C2 21925 10.0
TCTCTCAGTC Anxa5 Annexin A5 11747 9.0
CACAGAACCA 0610031J06 RIKEN cDNA 0610031J06 gene 56700 7.0
CCTGCAGCAG 2900073H19 RIKEN cDNA 2900073H19 gene 68205 7.0
GCCACTTAAG Cd79a CD79A antigen (immunoglubulin-associated alpha) 12518 -15.0
AGCCATCATA 2610042O14 RIKEN cDNA 2610042O14 gene 66460 -13.0
AGCGAAATAA Gmfg Glia maturation factor gamma 63986 -11.0
CTGCAGCCTA Stx5a Syntaxin 5A 56389 -11.0
TTACAAGCCT Cks1b CDC28 protein kinase 1b 54124 -10.0
GTGGACTCAA Ifitm1 Interferon induced transmembrane protein 1 68713 -10.0
CATAGTTTAA Nol7 Nucleolar protein 7 70078 -10.0
AAGTTCTTCA Csn1s2a Casein alpha s2-like A 12993 -9.0
C3(1) SV40 T-antigen     
AGCAGTGCTT Ccdc3 Coiled-coil domain containing 3 74186 13.0
CAGTTTGTAA Pdha1 Pyruvate dehydrogenase E1 alpha 1 18597 10.0
AATGTGTATG Abca8a ATP-binding cassette sub-family A (ABC1) 217258 9.0
ATTCCCTGTT Krtap8-1 Keratin associated protein 8-1 16703 8.0
CCGAAAAAAA Pink1 PTEN induced putative kinase 1 68943 7.0
ACTCTAAAAA Tmem55b Transmembrane protein 55b 219024 7.0
CTGTAGTGTC Ltf Lactotransferrin 17002 7.0
CTGTCCAAGG Bhlhb2 Basic helix-loop-helix domain containing class B2 20893 7.0
GAAAATAAAA Fndc3a Fibronectin type III domaing containing 3a 319448 -20.0
TAAATTAAGA Hexb Hexosaminidase B 15212 -16.0
TTAGAAGTGA Sav1 Salvador homolog 1 (Drosophila) 64010 -15.0
GGGGGTGAGG Hisppd1 Histidene acid phosphatase domain containing 1 227399 -15.0
TAACAAAGGA Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 229709 -14.0
GATTAAAACA 4931406I20 RIKEN cDNA 4931406I20 gene 66743 -11.0
TTAACACTGT Rab35 RAB35, member RAS oncogene family 77407 -10.0
CAGATTAAAA Gbp6 Guanylate binding protein 6 229900 -9.0
  1. *Up-regulated transcripts in bexarotene treatment are represented by positive fold changes and down-regulated transcripts are represented by negative fold changes.