Table 1 Most highly deregulated transcripts in mammary gland induced by bexarotene treatment on each transgenic mice mammary cancer model (Fold change ≥ 7; p < 0.01).
Tag | Gene | Description | Entrez Gene | Fold Change* |
|---|---|---|---|---|
p53-null | Â | Â | Â | Â |
GTTTGCTGTA | Serpinb6a | Serine (or cysteine) peptidase inhibitor | 20719 | 17.0 |
AGTCTCGAGG | Slc1a5 | Solute carrier family 1 | 20514 | 12.0 |
GGTTTGGGGG | Jup | Junction plakoglobin | 16480 | 11.0 |
TGCGTGCTGG | Timp2 | Tissue inhibitor of metalloproteinase 2 | 21858 | 11.0 |
TTGAAATTAC | BC061494 | CDNA sequence | 381832 | 11.0 |
GATTTCTTTG | Gpc3 | Glypican 3 | 14734 | 10.0 |
TAACCAAAAA | Itgb4 | Integrin beta 4 | 192897 | 10.0 |
CCCAGTCCCT | Ltbp4 | Latent transforming growth factor bindin. prot. 4 | 108075 | 8.0 |
GACTCTATAT | Csn2 | Casein beta | 12991 | -15.0 |
CAATAAAACA | Sar1b | SAR1 gene homolog B (S. Cerevisiae) | 66397 | -11.0 |
GCAGCGATTC | Nme2 | Expressed in non-metastatic cells 2 | 18103 | -10.0 |
TGTTCTATGG | Laptm5 | Lysosomal-associated protein transmembrane 5 | 16792 | -9.0 |
GTGTTTTGCT | AI451557 | Expressed sequence | 102084 | -9.0 |
CTAGGTGGTG | Glycam1 | Glycosylation dependent cell adhesion molecule 1 | 14663 | -8.8 |
TAAAGTCAAT | Muc15 | Mucin15 | 269328 | -8.0 |
TCAGAGTGAG | Igh-6 | Immunoglobulin heavy chain 6 | 16019 | -7.5 |
MMTV-erbB2 | Â | Â | Â | Â |
AGACCCTGTC | Pnpla3 | Patatin-like phospholipase domain containing 3 | 116939 | 44.0 |
TATGAGATAG | Timm9 | Translocase of inner mitochondrial membrane 9 | 30056 | 15.0 |
AGCCCTCGGA | Acads | Acyl-Coenzyme A dehydrogenase | 11409 | 12.0 |
ACCGGGCTGG | Elovl6 | ELOVL family member 6 | 170439 | 12.0 |
TGACAGAAGA | Tnnc2 | Troponin C2 | 21925 | 10.0 |
TCTCTCAGTC | Anxa5 | Annexin A5 | 11747 | 9.0 |
CACAGAACCA | 0610031J06 | RIKEN cDNA 0610031J06 gene | 56700 | 7.0 |
CCTGCAGCAG | 2900073H19 | RIKEN cDNA 2900073H19 gene | 68205 | 7.0 |
GCCACTTAAG | Cd79a | CD79A antigen (immunoglubulin-associated alpha) | 12518 | -15.0 |
AGCCATCATA | 2610042O14 | RIKEN cDNA 2610042O14 gene | 66460 | -13.0 |
AGCGAAATAA | Gmfg | Glia maturation factor gamma | 63986 | -11.0 |
CTGCAGCCTA | Stx5a | Syntaxin 5A | 56389 | -11.0 |
TTACAAGCCT | Cks1b | CDC28 protein kinase 1b | 54124 | -10.0 |
GTGGACTCAA | Ifitm1 | Interferon induced transmembrane protein 1 | 68713 | -10.0 |
CATAGTTTAA | Nol7 | Nucleolar protein 7 | 70078 | -10.0 |
AAGTTCTTCA | Csn1s2a | Casein alpha s2-like A | 12993 | -9.0 |
C3(1) SV40 T-antigen | Â | Â | Â | Â |
AGCAGTGCTT | Ccdc3 | Coiled-coil domain containing 3 | 74186 | 13.0 |
CAGTTTGTAA | Pdha1 | Pyruvate dehydrogenase E1 alpha 1 | 18597 | 10.0 |
AATGTGTATG | Abca8a | ATP-binding cassette sub-family A (ABC1) | 217258 | 9.0 |
ATTCCCTGTT | Krtap8-1 | Keratin associated protein 8-1 | 16703 | 8.0 |
CCGAAAAAAA | Pink1 | PTEN induced putative kinase 1 | 68943 | 7.0 |
ACTCTAAAAA | Tmem55b | Transmembrane protein 55b | 219024 | 7.0 |
CTGTAGTGTC | Ltf | Lactotransferrin | 17002 | 7.0 |
CTGTCCAAGG | Bhlhb2 | Basic helix-loop-helix domain containing class B2 | 20893 | 7.0 |
GAAAATAAAA | Fndc3a | Fibronectin type III domaing containing 3a | 319448 | -20.0 |
TAAATTAAGA | Hexb | Hexosaminidase B | 15212 | -16.0 |
TTAGAAGTGA | Sav1 | Salvador homolog 1 (Drosophila) | 64010 | -15.0 |
GGGGGTGAGG | Hisppd1 | Histidene acid phosphatase domain containing 1 | 227399 | -15.0 |
TAACAAAGGA | Ahcyl1 | S-adenosylhomocysteine hydrolase-like 1 | 229709 | -14.0 |
GATTAAAACA | 4931406I20 | RIKEN cDNA 4931406I20 gene | 66743 | -11.0 |
TTAACACTGT | Rab35 | RAB35, member RAS oncogene family | 77407 | -10.0 |
CAGATTAAAA | Gbp6 | Guanylate binding protein 6 | 229900 | -9.0 |