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Table 3 Plasma protein concentration ranges of selected proteins.

From: A high confidence, manually validated human blood plasma protein reference set

Plasma protein Known protein concentrations (g/ml) Distinct peptides Mass (Da)
Serum albumin 3.5 – 5.2 × 10-2 94 69367
Fibrinogen (alpha chain) 2.0 – 4.0 × 10-3 96 94973
Alpha-2-macroglobulin (male adult) 0.9 – 4.0 × 10-3 164 163278
Alpha-1-antitrypsin 7.8 – 20 × 10-4 44 46737
Haptoglobin 3.0 – 22 × 10-4 52 45205
Transthyretin, Thyroxine-binding prealbumin 2.8 – 3.5 × 10-4 19 15887
Ceruloplasmin 1.5 – 6.0 × 10-4 95 122205
Prothrombin 1.0 × 10-4 53 70037
Fletcher factor (Plasma kallikrein precursor) 5.0 × 10-5 37 71370
Complement component C6 4.8 – 6.4 × 10-5 61 104844
Complement component C9 4.7 – 6.9 × 10-5 32 63174
Hageman factor (Coagulation factor XII) 2.9 × 10-5 27 67818
Complement C1r component 2.5 – 3.8 × 10-5 45 80174
Properdin (Factor P) 2.4 – 3.2 × 10-5 2 51276
Complement C2 2.2 – 3.4 × 10-5 45 83268
Von Willebrand factor 7 × 10-6 55 309299
Stuart factor (Coagulation factor X) 5.0 × 10-6 18 54732
Christmas factor (Coagulation factor IX) 4.0 × 10-6 16 51748
Transferrin soluble receptor (adult), Serotransferrin 0.8 – 1.8 × 10-6 89 77050
Proconvertin (Coagulation factor VII) 1.0 × 10-6 * 53043
Mannose-binding protein C (MBP) 0.3 – 4.1 × 10-6 14 26144
Beta-2-microglobulin 8.0 – 24 × 10-7 8 13715
Antihemophilic factor (Coagulation factor VIII) 1.0 × 10-7 --- 267009
C-reactive protein, splice isoform 1 6.8 – 820 × 10-8 8 25039
Insulin-like growth factor II 9.9 – 50 × 10-8 5 20140
Myoglobin 6.0 – 85 × 10-9 4 17053
Prolactin (male), awake 1.0 – 7.0 × 10-9 --- 25876
Insulin 2.0 – 8.4 × 10-10 --- 11981
  1. Included in the table are proteins identified in our high confidence set of plasma proteins that represent a wide range of protein molecular weights and which have known plasma protein concentrations. Also included are some proteins that are known to be of higher abundance, but which were not detected in our experiments, and these were included to demonstrate that fact. The protein name, known plasma protein concentration, the number of unique peptides identifying the protein, the summed Mascot score and the MW is shown and the table has been sorted in descending order with the protein possessing the highest known protein concentration listed first.
  2. --- indicates that this entry was not identified in this study.
  3. * indicates that this entry was identified but not validated.