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Table 3 Plasma protein concentration ranges of selected proteins.

From: A high confidence, manually validated human blood plasma protein reference set

Plasma protein

Known protein concentrations (g/ml)

Distinct peptides

Mass (Da)

Serum albumin

3.5 – 5.2 × 10-2

94

69367

Fibrinogen (alpha chain)

2.0 – 4.0 × 10-3

96

94973

Alpha-2-macroglobulin (male adult)

0.9 – 4.0 × 10-3

164

163278

Alpha-1-antitrypsin

7.8 – 20 × 10-4

44

46737

Haptoglobin

3.0 – 22 × 10-4

52

45205

Transthyretin, Thyroxine-binding prealbumin

2.8 – 3.5 × 10-4

19

15887

Ceruloplasmin

1.5 – 6.0 × 10-4

95

122205

Prothrombin

1.0 × 10-4

53

70037

Fletcher factor (Plasma kallikrein precursor)

5.0 × 10-5

37

71370

Complement component C6

4.8 – 6.4 × 10-5

61

104844

Complement component C9

4.7 – 6.9 × 10-5

32

63174

Hageman factor (Coagulation factor XII)

2.9 × 10-5

27

67818

Complement C1r component

2.5 – 3.8 × 10-5

45

80174

Properdin (Factor P)

2.4 – 3.2 × 10-5

2

51276

Complement C2

2.2 – 3.4 × 10-5

45

83268

Von Willebrand factor

7 × 10-6

55

309299

Stuart factor (Coagulation factor X)

5.0 × 10-6

18

54732

Christmas factor (Coagulation factor IX)

4.0 × 10-6

16

51748

Transferrin soluble receptor (adult), Serotransferrin

0.8 – 1.8 × 10-6

89

77050

Proconvertin (Coagulation factor VII)

1.0 × 10-6

*

53043

Mannose-binding protein C (MBP)

0.3 – 4.1 × 10-6

14

26144

Beta-2-microglobulin

8.0 – 24 × 10-7

8

13715

Antihemophilic factor (Coagulation factor VIII)

1.0 × 10-7

---

267009

C-reactive protein, splice isoform 1

6.8 – 820 × 10-8

8

25039

Insulin-like growth factor II

9.9 – 50 × 10-8

5

20140

Myoglobin

6.0 – 85 × 10-9

4

17053

Prolactin (male), awake

1.0 – 7.0 × 10-9

---

25876

Insulin

2.0 – 8.4 × 10-10

---

11981

  1. Included in the table are proteins identified in our high confidence set of plasma proteins that represent a wide range of protein molecular weights and which have known plasma protein concentrations. Also included are some proteins that are known to be of higher abundance, but which were not detected in our experiments, and these were included to demonstrate that fact. The protein name, known plasma protein concentration, the number of unique peptides identifying the protein, the summed Mascot score and the MW is shown and the table has been sorted in descending order with the protein possessing the highest known protein concentration listed first.
  2. --- indicates that this entry was not identified in this study.
  3. * indicates that this entry was identified but not validated.
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BMC Medical Genomics

ISSN: 1755-8794

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