Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells

BMC Medical Genomics

Table 1 GSEA gene set analysis of PKA subunit regulated genes versus human myotube differentiation data.

NAME	SIZE	ES	NES	NOM p-val	FDR q-val
MYOTUBE_UPREG	250	0.889	1.607	0.007	0.005
RIIB_UPREG_OC_AFFY_TOP250	143	0.335	1.465	0.008	0.037
RIA_DOWNREG_OC_ILLUMINA_TOP250	225	0.357	1.368	0.03	0.057
RIIB_UPREG_OC_ILLUMINA_TOP250	199	0.337	1.363	0.037	0.048
RIA_DOWNREG_OC_AFFY_TOP250	157	0.317	1.221	0.14	0.145
MYOTUBE_DOWNREG	250	-0.857	-1.563	0.007	0.014
RIIB_DOWNREG_OC_ILLUMINA_TOP250	222	-0.418	-1.496	0.012	0.021
RIA_UPREG_OC_ILLUMINA_TOP250	175	-0.305	-1.148	0.254	0.51
RIIB_DOWNREG_OC_AFFY_TOP250	178	-0.296	-1.038	0.369	0.451
RIA_UPREG_OC_AFFY_TOP250	153	-0.24	-0.932	0.591	0.563

The top 250 up- or down-regulated genes from either RIα or RIIβ cells were derived from independent measurements made on either Affymetrix or Illumina microarrays and tested against the results of a human myotube versus myoblast comparison dataset. Bolded rows indicate statically significant results (FDR q-val < 0.25). MYOTUBE_UP and MYOTUBE_DOWN are control genelists derived from the top 250 up- or down-regulated genes derived directly from the myotube dataset. Size refers to the number of genes in the dataset found using a particular gene list, ES = enrichment score, NES = normalized enrichment score, NOM = nominal p-value following permutation analysis, FDR = false discovery rate (multiple comparisons correction), FWER = family wise error rate. For a complete discussion of this method see GSEA Algorithm.

ISSN: 1755-8794