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Table 1 GSEA gene set analysis of PKA subunit regulated genes versus human myotube differentiation data.

From: Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells

NAME SIZE ES NES NOM p-val FDR q-val
MYOTUBE_UPREG 250 0.889 1.607 0.007 0.005
RIIB_UPREG_OC_AFFY_TOP250 143 0.335 1.465 0.008 0.037
RIA_DOWNREG_OC_ILLUMINA_TOP250 225 0.357 1.368 0.03 0.057
RIIB_UPREG_OC_ILLUMINA_TOP250 199 0.337 1.363 0.037 0.048
RIA_DOWNREG_OC_AFFY_TOP250 157 0.317 1.221 0.14 0.145
MYOTUBE_DOWNREG 250 -0.857 -1.563 0.007 0.014
RIIB_DOWNREG_OC_ILLUMINA_TOP250 222 -0.418 -1.496 0.012 0.021
RIA_UPREG_OC_ILLUMINA_TOP250 175 -0.305 -1.148 0.254 0.51
RIIB_DOWNREG_OC_AFFY_TOP250 178 -0.296 -1.038 0.369 0.451
RIA_UPREG_OC_AFFY_TOP250 153 -0.24 -0.932 0.591 0.563
  1. The top 250 up- or down-regulated genes from either RIα or RIIβ cells were derived from independent measurements made on either Affymetrix or Illumina microarrays and tested against the results of a human myotube versus myoblast comparison dataset. Bolded rows indicate statically significant results (FDR q-val < 0.25). MYOTUBE_UP and MYOTUBE_DOWN are control genelists derived from the top 250 up- or down-regulated genes derived directly from the myotube dataset. Size refers to the number of genes in the dataset found using a particular gene list, ES = enrichment score, NES = normalized enrichment score, NOM = nominal p-value following permutation analysis, FDR = false discovery rate (multiple comparisons correction), FWER = family wise error rate. For a complete discussion of this method see GSEA Algorithm.
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BMC Medical Genomics

ISSN: 1755-8794

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