Figure 2
Arsenic-responsive interactome. Arsenic-interacting genes were evaluated for enrichment of molecular interactions. Ingenuity Pathway Analysis identified a large interaction network of 105 proteins enriched with roles in cell cycle control, apoptosis, DNA repair, and associated significantly with cancer (p < 10-34 based on the hypergeometric distribution and calculated with the right-tailed Fisher's Exact Test; dotted and solid lines indicate indirect and direct interactions, respectively).