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Table 3 Most frequently curated arsenic-interacting genes

From: The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study

No.
Curated
Interactions
No.
Interacting
As
Compounds1
Gene Molecular
Function2
Biological
Process2
44 9 HMOX1 Heme oxygenase Heme oxidation
21 3 BCL2 Protein binding Regulation of apoptosis
21 6 JUN Transcription factor Regulation of transcription, DNA-dependent
19 6 ABCC2 ATP-binding transporter Transport
19 6 MAPK1 MAP kinase Protein amino acid phosphorylation
18 6 MAPK3 MAP kinase Protein amino acid phosphorylation
17 5 ABCC1 ATP binding Transport
17 4 CCND1 CDK regulator Regulation of cell cycle
17 5 CDKN2A Kinase Cell cycle arrest; regulation of cyclin dependent protein kinase activity
16 6 AS3MT S-adenosylmethionine-dependent methyltransferase Arsonoacetate metabolism; toxin metabolism
16 3 MYC Transcription factor Regulation of transcription, DNA-dependent
15 3 VEGFA Growth factor Angiogenesis; anti-apoptosis; cell cycle
14 4 GADD45A Protein binding Cell cycle arrest; DNA damage response
14 6 NQO1 NADPH dehydrogenase Electron transport
14 4 TP53 Transcription factor Regulation of transcription, DNA-dependent
13 5 AFP Carrier Transport
13 4 CDKN1A CDK inhibitor Cell cycle arrest
13 4 GSTP1 Glutathione transferase Metabolism
13 3 HSPA1A Unfolded protein binding Protein folding; response to unfolded protein
12 5 EGR1 Transcription factor Regulation of transcription, DNA-dependent
12 4 ESR1 Transcription factor Regulation of transcription, DNA-dependent
12 4 PCNA DNA polymerase processivity factor; DNA binding Regulation of DNA replication
11 5 DDIT3 Transcription factor Regulation of transcription, DNA-dependent
11 3 FOS Transcription factor Regulation of transcription, DNA-dependent
10 2 BAX Protein binding Regulation of apoptosis
  1. 1 Out of 21 total arsenic compounds curated from the literature (see Table 1)
  2. 2 Most frequently annotated GO terms are shown; complete list is available at CTD