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Table 3 Most frequently curated arsenic-interacting genes

From: The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study

No.

Curated

Interactions

No.

Interacting

As

Compounds1

Gene

Molecular

Function2

Biological

Process2

44

9

HMOX1

Heme oxygenase

Heme oxidation

21

3

BCL2

Protein binding

Regulation of apoptosis

21

6

JUN

Transcription factor

Regulation of transcription, DNA-dependent

19

6

ABCC2

ATP-binding transporter

Transport

19

6

MAPK1

MAP kinase

Protein amino acid phosphorylation

18

6

MAPK3

MAP kinase

Protein amino acid phosphorylation

17

5

ABCC1

ATP binding

Transport

17

4

CCND1

CDK regulator

Regulation of cell cycle

17

5

CDKN2A

Kinase

Cell cycle arrest; regulation of cyclin dependent protein kinase activity

16

6

AS3MT

S-adenosylmethionine-dependent methyltransferase

Arsonoacetate metabolism; toxin metabolism

16

3

MYC

Transcription factor

Regulation of transcription, DNA-dependent

15

3

VEGFA

Growth factor

Angiogenesis; anti-apoptosis; cell cycle

14

4

GADD45A

Protein binding

Cell cycle arrest; DNA damage response

14

6

NQO1

NADPH dehydrogenase

Electron transport

14

4

TP53

Transcription factor

Regulation of transcription, DNA-dependent

13

5

AFP

Carrier

Transport

13

4

CDKN1A

CDK inhibitor

Cell cycle arrest

13

4

GSTP1

Glutathione transferase

Metabolism

13

3

HSPA1A

Unfolded protein binding

Protein folding; response to unfolded protein

12

5

EGR1

Transcription factor

Regulation of transcription, DNA-dependent

12

4

ESR1

Transcription factor

Regulation of transcription, DNA-dependent

12

4

PCNA

DNA polymerase processivity factor; DNA binding

Regulation of DNA replication

11

5

DDIT3

Transcription factor

Regulation of transcription, DNA-dependent

11

3

FOS

Transcription factor

Regulation of transcription, DNA-dependent

10

2

BAX

Protein binding

Regulation of apoptosis

  1. 1 Out of 21 total arsenic compounds curated from the literature (see Table 1)
  2. 2 Most frequently annotated GO terms are shown; complete list is available at CTD