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Table 4 GO and KEGG annotations for arsenic-interacting genes

From: The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study

GO-Molecular Function (top 10 out of 1042 total) Genes1
Protein binding 826
Metal ion binding 261
DNA binding 254
Nucleotide binding 243
ATP binding 203
Zinc ion binding 193
Transferase activity 181
Hydrolase activity 173
Transcription factor activity 157
Receptor activity 152
GO-Biological Process (top 10 out of 2093 total) Genes 1
Regulation of transcription, DNA-dependent 229
Signal transduction 227
Transcription 190
Multicellular organismal development 130
Apoptosis 121
Transport 121
Protein amino acid phosphorylation 112
Cell cycle 110
Immune response 104
Cell proliferation 88
GO-Cellular Component (top 10 out of 383 total) Genes 1
Nucleus 493
Cytoplasm 464
Membrane 438
Integral to membrane 295
Extracellular space 266
Extracellular region 216
Plasma membrane 176
Intracellular 156
Cytosol 121
Integral to plasma membrane 116
KEGG Pathway (top 10 out of 182 total) Genes 1
MAPK signaling pathway 89
Cytokine-cytokine receptor interaction 77
Focal adhesion 72
Cell cycle 56
Apoptosis 48
p53 Signaling pathway 44
Toll-like receptor signaling pathway 42
Regulation of actin cytoskeleton 41
ErbB Signaling pathway 39
Jak-STAT signaling pathway 38
  1. 1 Some genes are counted in more than one annotation category