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Table 4 GO and KEGG annotations for arsenic-interacting genes

From: The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study

GO-Molecular Function (top 10 out of 1042 total)

Genes1

Protein binding

826

Metal ion binding

261

DNA binding

254

Nucleotide binding

243

ATP binding

203

Zinc ion binding

193

Transferase activity

181

Hydrolase activity

173

Transcription factor activity

157

Receptor activity

152

GO-Biological Process (top 10 out of 2093 total)

Genes 1

Regulation of transcription, DNA-dependent

229

Signal transduction

227

Transcription

190

Multicellular organismal development

130

Apoptosis

121

Transport

121

Protein amino acid phosphorylation

112

Cell cycle

110

Immune response

104

Cell proliferation

88

GO-Cellular Component (top 10 out of 383 total)

Genes 1

Nucleus

493

Cytoplasm

464

Membrane

438

Integral to membrane

295

Extracellular space

266

Extracellular region

216

Plasma membrane

176

Intracellular

156

Cytosol

121

Integral to plasma membrane

116

KEGG Pathway (top 10 out of 182 total)

Genes 1

MAPK signaling pathway

89

Cytokine-cytokine receptor interaction

77

Focal adhesion

72

Cell cycle

56

Apoptosis

48

p53 Signaling pathway

44

Toll-like receptor signaling pathway

42

Regulation of actin cytoskeleton

41

ErbB Signaling pathway

39

Jak-STAT signaling pathway

38

  1. 1 Some genes are counted in more than one annotation category