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Figure 2 | BMC Medical Genomics

Figure 2

From: Expression-based Pathway Signature Analysis (EPSA): Mining publicly available microarray data for insight into human disease

Figure 2

Positive control validation for accuracy and specificity. Gene expression profiles were used to compare accuracy and specificity of signatures from Bild's study (panel A, used with permission) and EPSA (panel B). The profiles were derived from mammary tumors in mice transgenic for the MMTV-MYC, MMTV-HRAS or MMTV-HER2 oncogenes, from murine tumors dependent on loss of Rb, or from seven samples of normal murine mammary tissue. The predicted probability of Myc, E2F3 and Ras activity in these tumors was sorted from low (blue) to high (red), and displayed as a color bar. Both methods correctly ranked the appropriate test cases as highest scoring (whether probability or correlation) for the respective mutations. Myc gave the strongest signal in both methods, followed by Rb null and Ras, in that order. (Loss of Rb causes an increase in E2F3 expression.)

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BMC Medical Genomics

ISSN: 1755-8794

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