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Table 3 Information on biological processes based on Gene ontology.

From: Searching for molecular markers in head and neck squamous cell carcinomas (HNSCC) by statistical and bioinformatic analysis of larynx-derived SAGE libraries

Cell communication

 

Biological Process

Up-regulated genes

   signal transduction

CXCL14, OR4S2, RPS6KA1, TNFRSF18, TNFSF10

   cell-cell signaling

TOLLIP

Transcription

NRG1, SUMO1

Apoptosis

INCA

   induction

TNFSF10

   anti-apoptosis

PRKCZ, TNFRSF18

Cell-adhesion

MSLN

Cell cycle

CCND1, UBE2C

Cell proliferation

 

   negative regulation

EMP3

Cellular development process

 

   cell differentiation

KRT19

Developmental process

 

   organ development

KRT19

epidermis development

 

Response to stimulus

 

   defense response

 

inflammatory response

SERPINA3

   response to stress

 

response to oxidative stress

GPX2

   response to external stimulus

CXCL14, OR4S2

Transport

HBB

Metabolic process

NADK

   protein metabolic process

DKFZP586H2123, INCA, NRG1, SULF2, UBE2C, USP9X

protein modification process

CCND1, POMT2, PRKCZ, SUMO1, USP14

   lipid metabolic process

SERPINA3

   carbohydrate metabolic process

DCXR

   RNA metabolic process

PCBP2

RNA processing

RBM17

DNA repair

SUMO1

No classification:

ANXA7, BRD9, C6orf148, CMIP, FLJ23577, LOC283516, LOC283731, LOC388796, MFAP2, RRP15, SNCG, TMEM109, ZC3H7B

 

Down-regulated genes

Apoptosis

KLK8

   induction

IGFBP3

   anti-apoptosis

ANGPTL4

Cell adhesion

SAA1

Cell migration

SAA1

Cell cycle

 

   Negative regulation

KLK10

Cell proliferation

 

   Negative regulation

FGFBP1

   keratynocyte proliferation

KLK8

Cellular development process

 

   cell differentiation

IGFBP3, KLK8, SPON2

   keratinocyte differentiation

SPRR2E, SPRR2F, SPRR3

Developmental process

SPRR2E, SPRR2F

   organ development

 

ectoderm development

KRT6A

epidermis development

SPRR2E, SPRR2F, SPRR3

keratinization

SPRR2E, SPRR2F, SPRR3

Response to stimulus

 

   defense response

NCF1

inflammatory response

PI3, S100A8, S100A9,

   immune response

DEFB4, HLA-A, PI3, TAPBP

   response to stress

HIG2, KLK8

   response to external stimulus

KLK8, SAA1

Angiogenesis

ANGPTL4

Transport

ALDH3A1, HBA2, PGD

Metabolic process

ALDH3A1, TPI1

   protein metabolic process

TAPBP

protein modification process

CCT3, FKBP9L, HSPE1, IGFBP3

   lipid metabolic process

PLA2G4E, TPI1

   carbohydrate metabolic process

PGD, TPI1

Cellular homeostasis

SAA1

No classification

C10orf99, C9orf58, CAPNS2, FAM129B, GPRASP2, IGHA1, LMNA, LOC645960, LYPD2, MUC1, NOL6, PSME2, SLFN13, SNHG8, TJP2, TncRNA

  1. Top up- and down-regulated genes selected from SAGE in N+ tumor sample compared to N0 sample.