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Table 2 Listing of cancer associated hypermethylation markers that have been reported previously within the 250 highest ranking genes, as found by literature search (trough NCBI E-fetch, using GeneCards to search aliases)

From: Discovery of DNA methylation markers in cervical cancer using relaxation ranking

Gene symbol Rank Profile X-Y-Z Chromosomal location References
ZIK1 6 16-1-15 19q13.43 Intestinal metaplasia
[68]
NNAT 1,2 21 0-1-11 20q11.2-q12 Pediatric acute leukemia
[40]
SST 1 22 1-1-12 3q28 Colon cancer
[53]
SSX2 3 27 0-0-8 Xp11.23-p11.22 Bladder cancer
[69]
NPTX1 1 29 2-3-14 17q25.1-q25.2 Pancreatic cancer
[54]
PRSS21 72 18-3-15 16p13.3 Testicular cancer
[70, 71]
CYP1A1 1 76 0-0-7 15q22-q24 Prostate cancer
[72]
MAGEA3 1,3 96 4-2-12 Xq28 Different cancer cell lines (Leukemic, Hepatic, Prostate, Breast, Colon)
[73]
Hepatocellular carcinoma
[74]
Melanoma
[75]
INSR 124 7-0-9 19p13.3-p13.2 Prostate cancer
[50]
DLX1 150 2-3-12 2q32 Lung cancer
[76]
PAX9 207 25-1-12 14q12-q13 Lung cancer
[76]
ZNF342 228 0-0-6 19q13.32 Brain cancer
[77]
CCNA1 1,4 234 3-0-7 13q12.3-q13 Cervical cancer
[48]
Head-and neck cancer
[30]
Oral cancer
[52]
CTCFL 245 14-0-9 20q13.31 Prostate and bladder cancer
[78]
LIFR 248 32-3-15 5p13-p12 Hepatocellular carcinoma
[79]
  1. 1Genes, whose promoter has been described in literature as being methylated in certain cancer types selected by screening the PubMeth database. 2Imprinted. 3Located on the X-chromosome. 4Methylated in cervical cancer (literature search)