Table 2 Listing of cancer associated hypermethylation markers that have been reported previously within the 250 highest ranking genes, as found by literature search (trough NCBI E-fetch, using GeneCards to search aliases)
From: Discovery of DNA methylation markers in cervical cancer using relaxation ranking
Gene symbol | Rank | Profile X-Y-Z | Chromosomal location | References |
|---|---|---|---|---|
ZIK1 | 6 | 16-1-15 | 19q13.43 | Intestinal metaplasia [68] |
NNAT 1,2 | 21 | 0-1-11 | 20q11.2-q12 | Pediatric acute leukemia [40] |
SST 1 | 22 | 1-1-12 | 3q28 | Colon cancer [53] |
SSX2 3 | 27 | 0-0-8 | Xp11.23-p11.22 | Bladder cancer [69] |
NPTX1 1 | 29 | 2-3-14 | 17q25.1-q25.2 | Pancreatic cancer [54] |
PRSS21 | 72 | 18-3-15 | 16p13.3 | Testicular cancer |
CYP1A1 1 | 76 | 0-0-7 | 15q22-q24 | Prostate cancer [72] |
MAGEA3 1,3 | 96 | 4-2-12 | Xq28 | Different cancer cell lines (Leukemic, Hepatic, Prostate, Breast, Colon) [73] Hepatocellular carcinoma [74] Melanoma [75] |
INSR | 124 | 7-0-9 | 19p13.3-p13.2 | Prostate cancer [50] |
DLX1 | 150 | 2-3-12 | 2q32 | Lung cancer [76] |
PAX9 | 207 | 25-1-12 | 14q12-q13 | Lung cancer [76] |
ZNF342 | 228 | 0-0-6 | 19q13.32 | Brain cancer [77] |
CCNA1 1,4 | 234 | 3-0-7 | 13q12.3-q13 | Cervical cancer [48] Head-and neck cancer [30] Oral cancer [52] |
CTCFL | 245 | 14-0-9 | 20q13.31 | Prostate and bladder cancer [78] |
LIFR | 248 | 32-3-15 | 5p13-p12 | Hepatocellular carcinoma [79] |