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Table 3 Methylation status using COBRA of the 10 highest-ranking gene promoters.

From: Discovery of DNA methylation markers in cervical cancer using relaxation ranking

Rank Gene symbol Profile X-Y-Z Chromosomal location Methylation in cancer Methylation in normal
1 DAZL 1-1-13 3p24.3 9/9 5/5
2 ADARB1 1-2-15 21q22.3 Nd Nd
3 SYCP3 0-1-12 12q 9/9 5/5
4 AUTS2 12-0-12 7q11.22 0/9 0/5
5 NNAT 0-1-11 20q11.2 9/9 5/5
6 SST 1-1-12 3q28 7/9 0/5
7 HTRA3 6-0-10 4p16.1 1/9 0/5
8 ZFP42 11-1-14 4q35.2 9/9 5/5
9 NPTX1 2-3-14 17q25.1 5/10 0/5
10 GDA 14-3-15 9q21.13 0/9 0/5
47 CCNA1 3-0-7 13q12.3-q13 6/10 0/5
  1. Gene, selected for further validation after applying additional criteria. Included is CCNA1 on position 47 (original position 241) as the highest ranking cervical-cancer-associated hypermethylated gene (see Table 2). Methylation status was determined by BSP/COBRA (see Figure 3 and Figure 4).