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Table 3 Pathways deregulated after carboplatin exposure.

From: Carboplatin-induced gene expression changes in vitroare prognostic of survival in epithelial ovarian cancer

 

Pathway description

Genes

P-Value *

1

Oxidative Stress Induced Gene Expression Via Nrf2

29

< 0.0001

2

ATM Signaling Pathway

23

< 0.0001

3

Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy

16

< 0.0001

4

Pertussis toxin-insensitive CCR5 Signaling in Macrophage

12

< 0.0001

5

Cadmium induces DNA synthesis and proliferation in macrophages

14

< 0.0001

6

Cytokine Network

5

< 0.0001

7

Adhesion and Diapedesis of Granulocytes

6

< 0.0001

8

IL12 and Stat4 Dependent Signaling Pathway in Th1 Development

7

< 0.0001

9

Signal transduction through IL1R

27

< 0.0001

10

Cells and Molecules involved in local acute inflammatory response

12

< 0.0001

11

Adhesion and Diapedesis of Lymphocytes

10

< 0.0001

12

Bone Remodelling

12

< 0.0001

13

Regulation of hematopoiesis by cytokines

5

< 0.0001

14

Cytokines and Inflammatory Response

9

< 0.0001

15

IL 17 Signaling Pathway

8

< 0.0001

16

METS affect on Macrophage Differentiation

20

< 0.0001

17

NF-kB Signaling Pathway

22

< 0.0001

18

The 4-1BB-dependent immune response

16

0.000124

19

Inhibition of Cellular Proliferation by Gleevec

24

0.000125

20

Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa

47

0.000132

21

TNFR2 Signaling Pathway

16

0.00031

22

Activation of PKC through G protein coupled receptor

7

0.000423

23

TPO Signaling Pathway

30

0.000472

24

Eukaryotic protein translation

17

0.000796

25

Erythropoietin mediated neuroprotection through NF-kB

9

0.001252

26

NFkB activation by Nontypeable Hemophilus influenzae

29

0.001499

27

IFN alpha signaling pathway

12

0.00188

28

The information-processing pathway at the IFN-beta enhancer

15

0.002252

29

Hypoxia-Inducible Factor in the Cardiovascular System

22

0.002535

30

Free Radical Induced Apoptosis

10

0.002556

31

FAS signaling pathway (CD95)

45

0.002569

32

Keratinocyte Differentiation

39

0.002711

33

Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells

14

0.00285

34

Repression of Pain Sensation by the Transcriptional Regulator DREAM

13

0.002997

35

CD40L Signaling Pathway

17

0.003313

36

Nitric Oxide Signaling Pathway

6

0.0017

37

Induction of apoptosis through DR3 and DR4/5 Death Receptors

34

0.0046

38

SREBP control of lipid synthesis

7

0.0049

39

Regulation of transcriptional activity by PML

18

0.0029843

40

Double Stranded RNA Induced Gene Expression

10

0.0015

  1. * By Functional Class Scoring Method