Skip to main content

Table 3 Pathways deregulated after carboplatin exposure.

From: Carboplatin-induced gene expression changes in vitroare prognostic of survival in epithelial ovarian cancer

  Pathway description Genes P-Value *
1 Oxidative Stress Induced Gene Expression Via Nrf2 29 < 0.0001
2 ATM Signaling Pathway 23 < 0.0001
3 Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy 16 < 0.0001
4 Pertussis toxin-insensitive CCR5 Signaling in Macrophage 12 < 0.0001
5 Cadmium induces DNA synthesis and proliferation in macrophages 14 < 0.0001
6 Cytokine Network 5 < 0.0001
7 Adhesion and Diapedesis of Granulocytes 6 < 0.0001
8 IL12 and Stat4 Dependent Signaling Pathway in Th1 Development 7 < 0.0001
9 Signal transduction through IL1R 27 < 0.0001
10 Cells and Molecules involved in local acute inflammatory response 12 < 0.0001
11 Adhesion and Diapedesis of Lymphocytes 10 < 0.0001
12 Bone Remodelling 12 < 0.0001
13 Regulation of hematopoiesis by cytokines 5 < 0.0001
14 Cytokines and Inflammatory Response 9 < 0.0001
15 IL 17 Signaling Pathway 8 < 0.0001
16 METS affect on Macrophage Differentiation 20 < 0.0001
17 NF-kB Signaling Pathway 22 < 0.0001
18 The 4-1BB-dependent immune response 16 0.000124
19 Inhibition of Cellular Proliferation by Gleevec 24 0.000125
20 Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa 47 0.000132
21 TNFR2 Signaling Pathway 16 0.00031
22 Activation of PKC through G protein coupled receptor 7 0.000423
23 TPO Signaling Pathway 30 0.000472
24 Eukaryotic protein translation 17 0.000796
25 Erythropoietin mediated neuroprotection through NF-kB 9 0.001252
26 NFkB activation by Nontypeable Hemophilus influenzae 29 0.001499
27 IFN alpha signaling pathway 12 0.00188
28 The information-processing pathway at the IFN-beta enhancer 15 0.002252
29 Hypoxia-Inducible Factor in the Cardiovascular System 22 0.002535
30 Free Radical Induced Apoptosis 10 0.002556
31 FAS signaling pathway (CD95) 45 0.002569
32 Keratinocyte Differentiation 39 0.002711
33 Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells 14 0.00285
34 Repression of Pain Sensation by the Transcriptional Regulator DREAM 13 0.002997
35 CD40L Signaling Pathway 17 0.003313
36 Nitric Oxide Signaling Pathway 6 0.0017
37 Induction of apoptosis through DR3 and DR4/5 Death Receptors 34 0.0046
38 SREBP control of lipid synthesis 7 0.0049
39 Regulation of transcriptional activity by PML 18 0.0029843
40 Double Stranded RNA Induced Gene Expression 10 0.0015
  1. * By Functional Class Scoring Method