TY - JOUR AU - Bonifaci, Núria AU - Berenguer, Antoni AU - Díez, Javier AU - Reina, Oscar AU - Medina, Ignacio AU - Dopazo, Joaquín AU - Moreno, Víctor AU - Pujana, Miguel Angel PY - 2008 DA - 2008/12/18 TI - Biological processes, properties and molecular wiring diagrams of candidate low-penetrance breast cancer susceptibility genes JO - BMC Medical Genomics SP - 62 VL - 1 IS - 1 AB - Recent advances in whole-genome association studies (WGASs) for human cancer risk are beginning to provide the part lists of low-penetrance susceptibility genes. However, statistical analysis in these studies is complicated by the vast number of genetic variants examined and the weak effects observed, as a result of which constraints must be incorporated into the study design and analytical approach. In this scenario, biological attributes beyond the adjusted statistics generally receive little attention and, more importantly, the fundamental biological characteristics of low-penetrance susceptibility genes have yet to be determined. SN - 1755-8794 UR - https://doi.org/10.1186/1755-8794-1-62 DO - 10.1186/1755-8794-1-62 ID - Bonifaci2008 ER -